Evidence map›Paper›PMID 40196691›Full record

ArticlebioRxiv : the preprint server for biology2025

Protein-primed DNA homopolymer synthesis by an antiviral reverse transcriptase.

Stephen Tang, Rimantė Žedaveinytė, Nathaniel Burman, Shishir Pandey, Josephine L Ramirez, Louie M Kulber, Tanner Wiegand, Royce A Wilkinson, Yanzhe Ma, Dennis J Zhang and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Stephen TangDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-5492-9796
Rimantė ŽedaveinytėDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-0738-6976
Nathaniel BurmanDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.ORCID 0000-0002-3732-3159
Shishir PandeyDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.ORCID 0000-0002-7531-1538
Josephine L RamirezDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Louie M KulberDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Tanner WiegandDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Royce A WilkinsonDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.
Yanzhe MaDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Dennis J ZhangDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
George D LampeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Mirela BerisaMetabolomics Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marko JovanovicDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Blake WiedenheftDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-8240-9114

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP30GM140963 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2021 to 2025
$6.9M
Structural and functional understanding of bacterial defense and viral counter defenseR35GM134867 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Blake A Wiedenheft · 2020 to 2026
$3.8M
How dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changesR35GM152258 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Marko Jovanovic · 2024 to 2026
$1.6M
Mechanisms of reverse transcriptase mediated phage resistance in EnterobacteriaceaeF30AI183830 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen Tang · 2024 to 2026
$158k
CRISPR RNA-guided recognition of invading RNA activates a multipronged cell death responseF31GM153146 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI BURMAN, NATHANIEL · 2024 to 2025
$73k
NIAID NIH HHS F30 AI183830NIGMS NIH HHS F31 GM153146NIGMS NIH HHS P20 GM103474NIGMS NIH HHS P30 GM140963NIGMS NIH HHS R35 GM134867NIGMS NIH HHS R35 GM152258NIGMS NIH HHS T32 GM145440
6 · The paper itself

Abstract

Bacteria defend themselves from viral predation using diverse immune systems, many of which sense and target foreign DNA for degradation

Identifiers

PMID40196691
PMCPMC11974808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.