Evidence map›Paper›PMID 40196674›Full record

ArticlebioRxiv : the preprint server for biology2025

Optoretinography reveals rapid rod photoreceptor movement upon photoisomerization.

Huakun Li, Connor E Weiss, Vimal Prabhu Pandiyan, Davide Nanni, Teng Liu, Pei Wen Kung, Bingyao Tan, Veluchamy Amutha Barathi, Leopold Schmetterer, Ramkumar Sabesan and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Huakun LiSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.
Connor E WeissDepartment of Ophthalmology, University of Washington, Seattle, WA 98109, USA.
Vimal Prabhu PandiyanDepartment of Ophthalmology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0002-6996-0355
Davide NanniSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.
Teng LiuDepartment of Ophthalmology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0001-5610-2813
Pei Wen KungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Bingyao TanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Veluchamy Amutha BarathiSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Leopold SchmettererSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0002-7189-1707
Ramkumar SabesanDepartment of Ophthalmology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0003-0895-7037
Tong LingSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0001-9009-7966

Funding

Optoretinography: All-optical measures of functional activity in the human retinaU01EY032055 · NEI · UNIVERSITY OF WASHINGTON · PI PALANKER, DANIEL V, ROORDA, AUSTIN · 2021 to 2025
$5.2M
Photoreceptor mosaic in health and diseaseR01EY029710 · NEI · UNIVERSITY OF WASHINGTON · PI Ramkumar Sabesan · 2019 to 2026
$2.9M
NEI NIH HHS R01 EY029710NEI NIH HHS U01 EY032055NIAID NIH HHS L30 AI172024NIAID NIH HHS L40 AI172024
6 · The paper itself

Abstract

Rod photoreceptors are essential for vision under dim light conditions. The onset of rod-mediated vision is marked by the isomerization of rhodopsin. Here we demonstrate that human and rodent rods undergo a minute and rapid contraction of their outer segments immediately upon photoisomerization. The contraction is explained as an electro-mechanical manifestation of the rod early receptor potential generated in the disk membranes, which is challenging to access in electrophysiology. The bleach-strength dependence of the contraction was accounted by a voltage-dependent membrane tension model, developed earlier to explain a similar behavior in cones. The

Identifiers

PMID40196674
PMCPMC11974685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.