Evidence map›Paper›PMID 40196668›Full record

ArticlebioRxiv : the preprint server for biology2025

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling.

Sara Alonso, Harsimran Kaur, Luo Jia, Mai-Uyen Nguyen, Alyssa Laguerta, Andrew Fong, Neema Skariah, Rafael J Argüello, Michael P Verzi, Mahima Swamy and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sara Alonso
Luo Jia
Mai-Uyen Nguyen
Alyssa Laguerta
Andrew Fong
Neema Skariah
Rafael J ArgüelloORCID 0000-0001-9785-3883
Michael P Verzi

Funding

CD39 in gamma delta intraepithelial lymphocyte functionR01DK141146 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Karen Leigh Edelblum · 2024 to 2026
$2.0M
Interferon regulation of gamma delta intraepithelial lymphocyte activationR01DK119349 · NIDDK · RBHS-NEW JERSEY MEDICAL SCHOOL · PI EDELBLUM, KAREN LEIGH · 2019 to 2023
$1.8M
Microbiota-gamma delta IEL-Paneth cell axis in host antimicrobial responseR21AI171959 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI EDELBLUM, KAREN LEIGH · 2022 to 2023
$439k
NIAID NIH HHS R21 AI171959NIDDK NIH HHS R01 DK119349NIDDK NIH HHS R01 DK141146
6 · The paper itself

Abstract

Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferative γδ IEL (γδ

Identifiers

PMID40196668
PMCPMC11974730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.