Evidence map›Paper›PMID 40196614›Full record

ArticlebioRxiv : the preprint server for biology2025

CRISPR-Cas12a REC2 - NUC interactions drive target-strand cleavage and constrain trans cleavage.

Anthony Newman, Aakash Saha, Lora Starrs, Pablo R Arantes, Giulia Palermo, Gaetan Burgio

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Anthony NewmanThe Shine-Dalgarno Centre for RNA Innovation, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia.ORCID 0009-0001-6093-0010
Aakash SahaDepartment of Bioengineering, University of California Riverside, 900 University Avenue, 92512 Riverside, CA, USA.ORCID 0000-0003-0776-9771
Lora StarrsThe Shine-Dalgarno Centre for RNA Innovation, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia.ORCID 0000-0001-5771-4969
Pablo R ArantesDepartment of Bioengineering, University of California Riverside, 900 University Avenue, 92512 Riverside, CA, USA.
Giulia PalermoDepartment of Bioengineering, University of California Riverside, 900 University Avenue, 92512 Riverside, CA, USA.ORCID 0000-0003-1404-8737
Gaetan BurgioThe Shine-Dalgarno Centre for RNA Innovation, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia.ORCID 0000-0002-7434-926X

Funding

Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9R01GM141329 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI PALERMO, GIULIA · 2021 to 2025
$1.7M
NIGMS NIH HHS R01 GM141329
6 · The paper itself

Abstract

CRISPR-Cas12a effects RNA-guided cleavage of dsDNA in

Identifiers

PMID40196614
PMCPMC11974684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.