Evidence map›Paper›PMID 40196579›Full record

ArticlebioRxiv : the preprint server for biology2025

Hao Shen, Eric M Lynch, Noel Jameson, Justin Decarreau, Chenyang Shi, Zibo Chen, William Sheffler, Miaomiao Xu, James J De Yoreo, Jesse G Zalatan and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hao ShenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8875-6491
Eric M LynchDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Noel JamesonDepartment of Chemistry, University of Washington, Seattle, WA, USA.
Justin DecarreauDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Chenyang ShiPhysical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Zibo ChenSchool of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
William ShefflerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Miaomiao XuState Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, Jiangsu, China.
James J De YoreoPhysical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Jesse G ZalatanDepartment of Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1458-0654
Justin M KollmanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.

Funding

TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
Spatial Organization in Biochemical Reaction NetworksR35GM124773 · NIGMS · UNIVERSITY OF WASHINGTON · PI Jesse George Zalatan · 2017 to 2026
$3.9M
Structure and function of metabolic enzyme assembliesR35GM149542 · NIGMS · UNIVERSITY OF WASHINGTON · PI Justin M Kollman · 2023 to 2026
$2.2M
NIGMS NIH HHS P41 GM103533NIGMS NIH HHS R35 GM124773NIGMS NIH HHS R35 GM149542
6 · The paper itself

Abstract

The design of multi-component nanomaterials is an outstanding challenge. Here, we describe the computational design of protein filaments with two or three distinct structural components that assemble into micron-scale, well-ordered fibers when mixed. CryoEM structure determination of four fiber designs was close to the computational design models. Filament assembly can be initiated by mixing the components, and modulated by addition and/or phosphorylation of designed regulatory subunits. This work demonstrates that regulatable multi-component protein filament systems can now be designed, opening the door to a wide range of engineered materials.

Identifiers

PMID40196579
PMCPMC11974854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.