ArticlebioRxiv : the preprint server for biology2025
Acid-Sensing Ion Channel 1a Deficiency Drives Endocrine Hypertension in Male Mice.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acid-sensing ion channel 1a (ASIC1a) is an H Methods: Radiotelemeters were implanted in 6- and 18-month-old male and female wild-type ( Results: Aged male Conclusions: These findings establish ASIC1a as a novel, sex-specific regulator of cardiovascular function, linking early corticosterone excess in male mice to hyperaldosteronism and implicating ASIC1a deficiency as a potential driver of endocrine-related hypertension. GRAPHICAL ABSTRACT:
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