Evidence map›Paper›PMID 40196531›Full record

ArticlebioRxiv : the preprint server for biology2025

Long-term editing of brain circuits in mice using an engineered electrical synapse.

Elizabeth Ransey, Gwenaëlle E Thomas, Elias Wisdom, Agustin Almoril-Porras, Ryan Bowman, Elise Adamson, Kathryn K Walder-Christensen, Jesse A White, Dalton N Hughes, Hannah Schwennesen and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Elizabeth RanseyHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Gwenaëlle E ThomasHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Elias WisdomDepartment of Neuroscience and Department of Cell Biology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA.
Agustin Almoril-PorrasDepartment of Neuroscience and Department of Cell Biology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA.
Ryan BowmanDept. of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
Elise AdamsonHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Kathryn K Walder-ChristensenHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Jesse A WhiteHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Dalton N HughesHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Hannah SchwennesenDept. of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
Caly FergusonHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Kay M TyeHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Stephen D MagueHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Longgang NiuDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Zhao-Wen WangDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Daniel Colón-RamosDepartment of Neuroscience and Department of Cell Biology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0223-7717
Rainbo HultmanDepartment of Molecular Physiology and Biophysics, Department of Psychiatry, University of Iowa, Iowa City, IA, 52242 USA.
Nenad BursacDept. of Biomedical Engineering, Duke University, Durham North Carolina 27708, USA.
Kafui DzirasaHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.ORCID 0000-0003-4280-9994

Funding

Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Powering the Brain: the Cell Biology of NeuroenergeticsDP1NS111778 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2018 to 2022
$5.9M
Precision editing of neural circuits using engineered electrical synapsesDP1MH132709 · NIMH · DUKE UNIVERSITY · PI Kafui Dzirasa · 2022 to 2026
$5.7M
Examination of the cell biology of the synapse and behaviorR35NS132156 · NINDS · YALE UNIVERSITY · PI DANIEL A COLON-RAMOS · 2023 to 2026
$4.6M
Cellular and molecular mechanisms that temporally and spatially restrict synapticR01NS076558 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2012 to 2022
$4.1M
Dissecting and modifying temporal dynamics underlying major depressive disorderR01MH120158 · NIMH · DUKE UNIVERSITY · PI DZIRASA, KAFUI · 2019 to 2023
$3.4M
MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSIONR01MH125430 · NIMH · DUKE UNIVERSITY · PI CARLSON, DAVID E, DZIRASA, KAFUI · 2021 to 2025
$2.9M
In Vitro and In Situ Engineering of Fibroblasts for Cardiac RepairR01HL132389 · NHLBI · DUKE UNIVERSITY · PI BURSAC, NENAD · 2016 to 2019
$2.0M
Engineering of Human Excitable Tissues from Unexcitable CellsR01HL126524 · NHLBI · DUKE UNIVERSITY · PI BURSAC, NENAD · 2016 to 2019
$1.9M
A fully biological platform for monitoring mesoscale neural activityR21EY029451 · NEI · DUKE UNIVERSITY · PI DZIRASA, KAFUI · 2018 to 2019
$473k
NEI NIH HHS R21 EY029451NHLBI NIH HHS R01 HL126524NHLBI NIH HHS R01 HL132389NHLBI NIH HHS U01 HL134764NIMH NIH HHS DP1 MH132709NIMH NIH HHS R01 MH120158NIMH NIH HHS R01 MH125430NINDS NIH HHS DP1 NS111778NINDS NIH HHS R01 NS076558NINDS NIH HHS R35 NS132156
6 · The paper itself

Abstract

Electrical signaling across distinct populations of brain cells underpins cognitive and emotional function; however, approaches that selectively regulate electrical signaling between two cellular components of a mammalian neural circuit remain sparse. Here, we engineered an electrical synapse composed of two connexin proteins found in

Indexed as

behaviorcircuit editingconnexinsdockingelectrical synapsesneuromodulation

Identifiers

PMID40196531
PMCPMC11974911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.