ArticlebioRxiv : the preprint server for biology2025
Polygenic Associations between Motor Behaviour, Neuromotor Traits, and Active Music Engagement in Four Cohorts.
T L Henechowicz, P L Coleman, D E Gustavson, Y N Mekki, S Nayak, R Nitin, A C Scartozzi, E S Tio, R van Klei, D Felsky and 2 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
T L HenechowiczMusic and Health Science Research Collaboratory, Faculty of Music, University of Toronto.ORCID 0000-0001-6680-2098 P L ColemanVanderbilt Genetics Institute, Vanderbilt University Medical Center.
R NitinVanderbilt Genetics Institute, Vanderbilt University Medical Center.
E S TioKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health.
R van KleiKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health.
M H ThautMusic and Health Science Research Collaboratory, Faculty of Music, University of Toronto.
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MStructural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROBERTSON, DAVID HERLIE · 1997 to 2016
$30.8MTRANSPORT EFFECTS OF ARACHIDONATE METABOLITES IN PERFUSED TUBULEP01DK038226 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BROWN, NANCY J. · 1986 to 2015
$22.1MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MTHE PHARMACOLOGY OF ASPIRINP50HL081009 · NHLBI · VANDERBILT UNIVERSITY · PI LIEBLER, DANIEL · 2006 to 2010
$16.3MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0MUnifying Genetics Epidemiology of Macular DegenerationR01EY012118 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AGARWAL, ANITA, HAINES, JONATHAN L · 2006 to 2015
$12.2MBuilding Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3MThe Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9MEpidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8MNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCI NIH HHS K07 CA172294NCI NIH HHS R01 CA162433NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NEI NIH HHS R01 EY012118NHGRI NIH HHS U01 HG004603NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS P01 HL056693NHLBI NIH HHS P50 HL081009NHLBI NIH HHS U19 HL065962NICHD NIH HHS DP2 HD098859NICHD NIH HHS K12 HD043483NICHD NIH HHS R01 HD074711NICHD NIH HHS R03 HD078567NIDCD NIH HHS F31 DC022482NIDCD NIH HHS R01 DC016977NIDDK NIH HHS P01 DK038226NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK080007NIDDK NIH HHS R24 DK096527NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIH HHS S10 OD017985NIH HHS S10 OD025092NINDS NIH HHS R01 NS032830NLM NIH HHS R01 LM010685
6 · The paper itselfAbstract
Phenotypic investigations have shown that actively engaging with music, i.e., playing a musical instrument or singing may be protective of motor decline in aging. For example, music training associated with enhanced sensorimotor skills accompanied by changes in brain structure and function. Although it is possible that the benefits of active music engagement "transfer" to benefits in the motor domain, it is also possible that the genetic architecture of motor behaviour and the motor system structure may influence active music engagement. This study investigated whether polygenic scores (PGS) for five behavioural motor traits, 12 neuromotor structural brain traits, and seven rates of change in brain structure traits trained from existing discovery genome-wide association studies (GWAS) predict active music engagement outcomes in four independent cohorts of unrelated individuals of European ancestry: the Canadian Longitudinal Study on Aging (CLSA; N=22,198), Wisconsin Longitudinal Study (WLS; N=4,605), Vanderbilt's BioVU Repository (BioVU; N=6,150), and Vanderbilt's Online Musicality study (OM; N=1,559). Results were meta-analyzed for each PGS main effect across outcomes and cohorts, revealing that PGS for a faster walking pace was associated with higher amounts of active music engagement. Within CLSA, a higher PGS for walking pace was associated with greater odds of engaging with music. Findings suggest a shared genetic architecture between motor function and active music engagement. Future intervention-based research should consider the genetic underpinnings of motor behavior when evaluating the effects of music engagement on motor function across the lifespan.
Indexed as
BioVUbrain structureCLSAgenetic correlationgold-MSImotor systemmusical achievementmusicalitymusic engagementmusic trainingpolygenic scoresWLS
Identifiers
PMID40196524
PMCPMC11974849
What OpenQuestion holds
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LicenceCC BY
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