Evidence map›Paper›PMID 40196517›Full record

ArticlebioRxiv : the preprint server for biology2025

PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB.

Jennifer J Readshaw, Lindsey A Doyle, Maria Puiu, Abigail Kelly, Andrew Nelson, Alex J Kaiser, Sydney McGuire, Julieta Peralta-Acosta, Darren L Smith, Barry L Stoddard and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jennifer J ReadshawDepartment of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.ORCID 0009-0007-5734-1470
Lindsey A DoyleDivision of Basic Sciences, Fred Hutchinson Cancer Center, 1100 Fairview Ave. N. Seattle WA 98019, USA.
Maria PuiuDepartment of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.
Abigail KellyDepartment of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.
Andrew NelsonDepartment of Applied Sciences, University of Northumbria, Newcastle Upon Tyne NE1 8ST, UK.
Alex J KaiserDivision of Basic Sciences, Fred Hutchinson Cancer Center, 1100 Fairview Ave. N. Seattle WA 98019, USA.
Sydney McGuireDepartment of Biology, Seattle University, 901 12 Ave. Seattle WA 98122, USA.
Julieta Peralta-AcostaDepartment of Biology, Seattle University, 901 12 Ave. Seattle WA 98122, USA.
Darren L SmithDepartment of Applied Sciences, University of Northumbria, Newcastle Upon Tyne NE1 8ST, UK.
Barry L StoddardDivision of Basic Sciences, Fred Hutchinson Cancer Center, 1100 Fairview Ave. N. Seattle WA 98019, USA.
Brett K KaiserDepartment of Biology, Seattle University, 901 12 Ave. Seattle WA 98122, USA.
Tim R BlowerDepartment of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
MegaTALS: hyperspecific reagents for targeted gene modification and correctionR01GM105691 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STODDARD, BARRY L. · 2014 to 2022
$2.7M
Characterization of the Bacterial BREX Phage Restriction System - Administrative SupplementR15GM140375 · NIGMS · SEATTLE UNIVERSITY · PI Brett Kian Kaiser · 2021 to 2026
$919k
NCI NIH HHS P30 CA015704NIGMS NIH HHS R01 GM105691NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R15 GM140375
6 · The paper itself

Abstract

BREX (

Indexed as

Bacteriophage exclusionBREXmetal-dependentnucleasePhage defence

Identifiers

PMID40196517
PMCPMC11974810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.