Evidence map›Paper›PMID 40196504›Full record

ArticlebioRxiv : the preprint server for biology2025

A single high-zinc activation enhancer can control two genes orientated head-to-head in

Hanwenheng Liu, Brian Earley, Adelita Mendoza, Patrick Hunt, Sean Teng, Daniel L Schneider, Kerry Kornfeld

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hanwenheng LiuDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63130, USA.ORCID 0000-0001-5695-4995
Brian EarleyDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63130, USA.ORCID 0000-0002-6707-6785
Adelita MendozaDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63130, USA.ORCID 0000-0001-8152-3839
Patrick HuntDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63130, USA.
Sean TengDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63130, USA.ORCID 0009-0007-3618-3522
Daniel L SchneiderDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63130, USA.
Kerry KornfeldDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63130, USA.ORCID 0000-0002-6042-5241

Funding

TRANSCRIPTIONAL REGULATION OF ZINC HOMEOSTASISR01GM068598 · NIGMS · WASHINGTON UNIVERSITY · PI KORNFELD, KERRY · 2003 to 2025
$5.3M
Regulation of zinc-dependent lysosome morphological restructuring, zinc trafficking and low zinc homeostasis in C. elegans and human model systemsK99GM146016 · NIGMS · WASHINGTON UNIVERSITY · PI MENDOZA, ADELITA D. · 2022 to 2023
$225k
Zinc is a Novel Ligand of Nuclear ReceptorsF31ES030622 · NIEHS · WASHINGTON UNIVERSITY · PI EARLEY, BRIAN JAMES · 2019 to 2020
$59k
NIEHS NIH HHS F31 ES030622NIGMS NIH HHS K99 GM146016NIGMS NIH HHS R01 GM068598
6 · The paper itself

Abstract

Enhancers play critical roles in gene expression, but a full understanding of their complex functions has yet to be defined. The cellular response to excess zinc levels in

Indexed as

C. elegansdivergent transcriptionenhancerhigh-zinc activation elementHZAZinc metabolism

Identifiers

PMID40196504
PMCPMC11974713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.