Evidence map›Paper›PMID 40196491›Full record

ArticlebioRxiv : the preprint server for biology2025

CFTR function in alveolar type 1 cells drives lung liquid secretion and host defense.

Sayahi Suthakaran, Sonya Homami, Deebly Chavez, Stephanie Tang, Sarah K L Moore, Chaya Sussman, Jimmy Zhang, Clemente J Britto, Alice Prince, Alison J May and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sayahi Suthakaran
Sonya Homami
Deebly Chavez
Stephanie Tang
Sarah K L Moore
Chaya Sussman
Jimmy Zhang
Clemente J BrittoORCID 0000-0002-1979-1151
Alice Prince
Alison J May
Jaymin J Kathiriya
Jaime L HookORCID 0000-0002-6630-0060

Funding

Research Supplement for Alveolar Responses to Viral Lung InfectionR01HL164821 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jaime Lynn Hook · 2022 to 2026
$2.6M
Sources and Regulation of Epithelial Stem/Progenitor Cells in Alveolar RegenerationR00HL155785 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KATHIRIYA, JAYMIN J · 2023 to 2025
$747k
NHLBI NIH HHS R00 HL155785NHLBI NIH HHS R01 HL164821
6 · The paper itself

Abstract

Loss of the liquid layer that lines the lung's air-facing surface underpins mechanisms of major lung diseases, but the development of therapies that restore liquid secretion is hampered by an incomplete understanding of the cell types that drive it. Here, we show CFTR function in alveolar type 1 (AT1) cells - a cell type that comprises 95% of the lung surface but is presumed to be unimportant in CFTR-related diseases - is critical to lung liquid secretion and the secretion-mediated clearance of particles and

Identifiers

PMID40196491
PMCPMC11974899

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.