Evidence map›Paper›PMID 40196345›Full record

ArticleFrontiers in medicine2025

Evaluating the efficacy of low-molecular-weight heparin in managing umbilical artery thrombosis during pregnancy: does it offer therapeutic benefits?

Peng Zhao, Yicheng Lu, Sitong Liu, Lidan Zhang, Chong Chen, Xiaofu Yang

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peng ZhaoDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yicheng LuDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Sitong LiuDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lidan ZhangDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chong ChenDepartment of Ultrasonography, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaofu YangDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Umbilical artery thrombosis (UAT) is a rare but serious pregnancy complication, potentially causing fetal growth restriction, distress, and stillbirth. Diagnosis relies on Doppler ultrasound and pathological assessment. Close monitoring and potential low-molecular-weight heparin (LMWH) therapy aim to prolong gestation and improve outcomes, but debate persists on its efficacy compared to expectant management. Methods: A retrospective study, conducted between January 2013 and December 2023, enrolled singleton pregnant women diagnosed with UAT during pregnancy. The experiment group included pregnant women who underwent LMWH with anti-coagulation therapy during pregnancy, while the expectant group comprised pregnancies that received standard prenatal care without any specific intervention for UAT. Results: The expectant group showed a significant increase in birth weight (expectant vs. experiment: 2434.40 ± 770.20 g vs. 1874.46 ± 717.83 g, Conclusion: Our study suggests that expectant therapy may offer substantial benefits compared to experimental therapy involving the administration of LMWH.

Indexed as

anti-coagulation therapybirth weightexpectant managementlow molecular weight heparinumbilical artery thrombosis

Identifiers

PMID40196345
PMCPMC11973098

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.