ArticlemedRxiv : the preprint server for health sciences2025
Pathway-Specific Polygenic Scores for Lithium Response for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder.
Nigussie T Sharew, Scott R Clark, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Janice M Fullerton, Liping Hou, Tatyana Shekhtman, Mazda Adli, Nirmala Akula and 152 more
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
162 authors.
Sergi Papiol
Urs Heilbronner
Franziska Degenhardt
Janice M Fullerton
Liping Hou
Tatyana Shekhtman
Mazda Adli
Nirmala Akula
Kazufumi Akiyama
Raffaella Ardau
Bárbara Arias
Roland Hasler
Hélène Richard-Lepouriel
Nader Perroud
Lena Backlund
Abesh Kumar Bhattacharjee
Frank Bellivier
Antonio Benabarre
Susanne Bengesser
Joanna M Biernacka
Armin Birner
Cynthia Marie-Claire
Pablo Cervantes
Hsi-Chung Chen
Caterina Chillotti
Sven Cichon
Cristiana Cruceanu
Piotr M Czerski
Nina Dalkner
Maria Del Zompo
J Raymond DePaulo
Bruno Étain
Stephane Jamain
Peter Falkai
Andreas J Forstner
Louise Frisen
Mark A Frye
Sébastien Gard
Julie S Garnham
Fernando S Goes
Maria Grigoroiu-Serbanescu
Andreas J Fallgatter
Sophia Stegmaier
Thomas Ethofer
Silvia Biere
Kristiyana Petrova
Ceylan Schuster
Kristina Adorjan
Monika Budde
Maria Heilbronner
Janos L Kalman
Mojtaba Oraki Kohshour
Daniela Reich-Erkelenz
Sabrina K Schaupp
Eva C Schulte
Fanny Senner
Thomas Vogl
Ion-George Anghelescu
Volker Arolt
Udo Dannlowski
Detlef E Dietrich
Christian Figge
Markus Jäger
Fabian U Lang
Georg Juckel
Carsten Konrad
Jens Reimer
Max Schmauß
Andrea Schmitt
Carsten Spitzer
Martin von Hagen
Jens Wiltfang
Jörg Zimmermann
Till F M Andlauer
Andre Fischer
Felix Bermpohl
Philipp Ritter
Silke Matura
Anna Gryaznova
Irina Falkenberg
Cüneyt Yildiz
Tilo Kircher
Julia Schmidt
Marius Koch
Kathrin Gade
Sarah Trost
Ida S Haussleiter
Martin Lambert
Anja C Rohenkohl
Vivien Kraft
Paul Grof
Ryota Hashimoto
Joanna Hauser
Stefan Herms
Per Hoffmann
Esther Jiménez
Jean-Pierre Kahn
Layla Kassem
Po-Hsiu Kuo
Tadafumi Kato
John Kelsoe
Sarah Kittel-Schneider
Ewa Ferensztajn-Rochowiak
Barbara König
Ichiro Kusumi
Gonzalo Laje
Mikael Landén
Catharina Lavebratt
Marion Leboyer
Susan G Leckband
Alfonso Tortorella
Mirko Manchia
Lina Martinsson
Michael J McCarthy
Susan McElroy
Francesc Colom
Vincent Millischer
Marina Mitjans
Francis M Mondimore
Palmiero Monteleone
Caroline M Nievergelt
Markus M Nöthen
Tomas Novák
Claire O'Donovan
Norio Ozaki
Andrea Pfennig
Claudia Pisanu
James B Potash
Andreas Reif
Eva Reininghaus
Guy A Rouleau
Janusz K Rybakowski
Martin Schalling
Peter R Schofield
Barbara W Schweizer
Giovanni Severino
Paul D Shilling
Katzutaka Shimoda
Christian Simhandl
Claire M Slaney
Alessio Squassina
Thomas Stamm
Pavla Stopkova
Mario Maj
Gustavo Turecki
Eduard Vieta
Julia Veeh
Biju Viswanath
Stephanie H Witt
Adam Wright
Peter P Zandi
Philip B Mitchell
Michael Bauer
Martin Alda
Marcella Rietschel
Francis J McMahon
Thomas G Schulze
Bernhard T Baune
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Background: Polygenic scores (PGSs) hold the potential to identify patients who respond favourably to specific psychiatric treatments. However, their biological interpretations remain unclear. In this study, we developed pathway-specific PGSs (PS Methods: Using sets of genes involved in pathways affected by lithium, we developed nine PS Results: Response to lithium was associated with PS Conclusion: PS
Identifiers
PMID40196273
PMCPMC11974776
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