Evidence map›Paper›PMID 40196268›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Umbilical cord blood pTau217 and BD-tau are associated with markers of neonatal hypoxia: a prospective cohort study.

Emma Payne, Fernando Gonzalez-Ortiz, Kaitlin Kramer, Thomas Payne, Shreeya Marathe, Neha Mahajan, Ashly Liu, Jessica Barry, Andrew Duckworth, Mitchell Brookes and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Emma PayneSt George Hospital, South Eastern Sydney Local Health District, New South Wales, Australia.ORCID 0000-0002-1877-6961
Fernando Gonzalez-OrtizDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID 0000-0001-7897-9456
Kaitlin KramerCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia.
Thomas PayneCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia.ORCID 0000-0002-5530-3717
Shreeya MaratheDepartment of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, New South Wales, Australia.
Neha MahajanDepartment of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, New South Wales, Australia.
Ashly LiuDepartment of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, New South Wales, Australia.
Jessica BarryDepartment of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, New South Wales, Australia.
Andrew DuckworthDepartment of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, New South Wales, Australia.
Mitchell BrookesDepartment of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, New South Wales, Australia.
Bradley de VriesSydney Institute for Women, Children and their Babies, Sydney Local Health District, New South Wales, Australia.ORCID 0000-0002-5620-0170
Benjamin MoranCritical Care Program, The George Institute of Global Health, Sydney, Australia.
Helen ManningDept of Obstetrics and Gynaecology, Central coast local health district, NSW.
Adrienne GordonCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID 0000-0003-3930-4354
David ZalcbergCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia.
Robert D SandersCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia.ORCID 0000-0003-0113-0328

Funding

Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Richard C Lennertz, Robert D Sanders · 2019 to 2026
$5.0M
NIA NIH HHS R01 AG063849
6 · The paper itself

Abstract

Objective: Current methods for early detection of hypoxic-ischemic encephalopathy (HIE) are limited by lack of specificity, cost, and time constraints. Blood tau protein concentrations reflect neuropathology in adults. This study examines tau as a potential HIE biomarker in neonates by relating cord blood levels to short-term fetomaternal outcomes. We aimed to examine 1) association of BD-tau with non-reassuring fetal status; 2) correlations between cord blood tau and other hypoxia biomarkers; 3) associations between tau levels and risk factors for fetomaternal morbidity; 4) associations between tau levels and short-term fetomaternal outcome. Methods: 107 maternal participants were prospectively recruited at Royal Prince Alfred Hospital-a large Australian tertiary referral centre. Simoa analysis detected umbilical cord blood pTau217 and brain-derived (BD)-tau levels. Results: Of 509 deliveries, cord blood was analysed in 107/110 recruited maternal participants. BD-tau correlated with non-reassuring fetal status (OR=3.0;95%CI=1.6- 5.7;p=0.001), though not when adjusting for mode of delivery and gestational age. BD-tau was higher in vaginal deliveries, and positively associated with pTau217, NfL, and lactate (p<0.001), and negatively associated with pH and base excess. pTau217 was higher in preterm neonates and was associated with neurofilament light chain (Spearman's rho=0.44,p<0.001). BD-tau and pTau217 were associated with maternal hypertension and placental abnormalities. Conclusions: Cord blood BD-tau correlates with surrogate markers of fetal hypoxia, whilst pTau217 may represent a marker of neurodevelopment. Further studies could explore whether these findings translate to clinical use of tau as an HIE biomarker. Funding: US National Institutes of Health (grant:R01AG063849-01).

Indexed as

asphyxiaHIEhypoxic–ischemic encephalopathytau

Identifiers

PMID40196268
PMCPMC11974770

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.