Evidence map›Paper›PMID 40196219›Full record

ArticleOTO open

Mental Health Disorders and Pain in Patients Undergoing Head and Neck Free Flap Surgery.

Kelly L Vittetoe, Marina Aweeda, Lily Gao, Christopher Naranjo, Liping Du, Xiaoke Feng, Wenda Ye, Alexander J Langerman, Kyle Mannion, James L Netterville and 6 more

Abstract read
In one paragraph

Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mental Health Risk Factors for Postoperative Pain in Head and Neck Free Flap Reconstruction Patients.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kelly L VittetoeVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.ORCID 0000-0002-9683-5242
Marina AweedaVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Lily GaoVanderbilt University School of Medicine Nashville Tennessee USA.
Christopher NaranjoVanderbilt University School of Medicine Nashville Tennessee USA.
Liping DuVanderbilt University Department of Biostatistics Nashville Tennessee USA.
Xiaoke FengVanderbilt University Department of Biostatistics Nashville Tennessee USA.
Wenda YeVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Alexander J LangermanVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Kyle MannionVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
James L NettervilleVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Eben L RosenthalVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Robert J SinardVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Michael C TopfVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Sarah L RohdeVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Alexander H GelbardVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.
Melanie D HicksVanderbilt Medical Center Department of Otolaryngology Nashville Tennessee USA.

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Augmented Reality to Guide Head and Neck Cancer SurgeryK08CA293255 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Michael Topf · 2024 to 2026
$645k
NCI NIH HHS K08 CA293255NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

Objective: Determine relationships between pain and mental health disorders (MHDs) in patients undergoing microvascular free flap reconstruction for head and neck cancer (HNC). Study Design: Retrospective cohort. Setting: Tertiary Care Institution in the Southeastern United States. Methods: Clinical data were manually abstracted from digital health records to obtain demographic, MHD, clinical outcomes, and pain data for HNC patients who underwent free flap reconstruction from 2017 to 2023. Univariate and multivariable regression analyses were performed to delineate relationships between MHDs and postoperative pain. Results: The study cohort comprised 283 patients. Ninety-four patients (33%) had preoperative MHDs, which were more common in women (42% vs 30%, Conclusion: Postoperative pain and MHDs are independently predictive of one another in patients with HNC undergoing microvascular free flap reconstruction. Higher POD5 pain is predicted by the presence of preoperative MHD, and the need for a new psychiatric medication postoperatively is predicted by higher POD1 pain. HNC surgeons should align themselves with psychiatrists, social workers, and other allied fields to meet the complex mental health needs of their patients both preoperatively and postoperatively.

Indexed as

head and neck cancermental health disordersmicrovascular reconstructionpostoperative pain

Identifiers

PMID40196219
PMCPMC11973587

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.