Evidence map›Paper›PMID 40196165›Full record

ArticleFrontiers in pediatrics2025

Gut microbiota dysbiosis in infantile cholestatic hepatopathy.

Yi Zou, Wenhao Ni, Yong Zhou, Dan Sun, Feng Chen, Xianyun Li

Abstract read
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi Zou *Department of Clinical Laboratory, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.
Wenhao Ni *Department of Technology, Puluo (Wuhan) Medical Biotechnology Co., Ltd., Wuhan, China.
Yong ZhouDepartment of Technology, Puluo (Wuhan) Medical Biotechnology Co., Ltd., Wuhan, China.
Dan SunDepartment of Neurology, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Feng ChenEmergency and Critical Care Medical Center, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xianyun LiDepartment of Clinical Laboratory, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cholestatic hepatopathy is common in infants. While many studies link gut microbiota to liver and gallbladder diseases, the relationship between infantile cholestatic hepatopathy (ICH) and gut microbiota remains unclear. Methods: We collected stool samples from 19 healthy controls and 33 infants with ICH aged ≤3 months, then determined the intestinal microbiota by 16S rDNA sequencing. The differences of microbiota structure and functional between the two groups were analyzed. Results: Alpha-diversity analysis showed that the Chao1 and ACE indexes were significantly higher in the ICH group than control group ( Conclusion: Gut microbiota dysbiosis is associated with infantile cholestatic hepatopathy, and

Indexed as

16S rDNAbiomarkerinfantile cholestatic hepatopathyintestinal microbiotaStreptococcus

Identifiers

PMID40196165
PMCPMC11973382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.