Evidence map›Paper›PMID 40196109›Full record

ReviewFrontiers in immunology2025

RNA modification: a promising code to unravel the puzzle of autoimmune diseases and CD4

Hui Yu, Zhanchuan Ma, Sensen Su, Zheng Xu, Huanfa Yi

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hui YuCentral Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China.
Zhanchuan MaCentral Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China.
Sensen SuCentral Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China.
Zheng Xu *Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, China.
Huanfa Yi *Central Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic changes in various forms of RNA modification are critical to the functional homeostasis of the immune system and the pathophysiology of autoimmune diseases. RNA modification-related proteins play an essential role in these processes. At present, the research methods of RNA modification in autoimmune diseases are mainly to detect the expression changes of RNA modification-related proteins in tissues or cells, but there is a lack of explorations of target RNAs and in-depth mechanisms. Considering the important role of CD4

Indexed as

Autoimmune DiseasesCD4-Positive T-LymphocytesCell DifferentiationRNARNA Processing, Post-TranscriptionalAnimalsHumansRNAautoimmune diseasesCD4+ T cellspost-transcriptional modificationRNA modificationT cell differentiation

Identifiers

PMID40196109
PMCPMC11973318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.