ArticleCureus2025
Association Between Thygeson Superficial Punctate Keratitis and Celiac Disease.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thygeson's superficial punctate keratitis (TSPK) is a rare, bilateral, chronic epithelial keratopathy characterized by recurrent exacerbations and remissions. Although its pathophysiology remains unclear, immunological and viral mechanisms have been implicated, with associations reported between TSPK and HLA-DR3. Similarly, celiac disease (CD) is an autoimmune disorder linked to HLA-DQ2 and HLA-DQ8, and HLA-DR3-DQ2. We report the case of a 20-year-old female with celiac disease who presented with TSPK. Clinical findings included stellate epithelial opacities and a pseudo-dendritic lesion, treated successfully with artificial tears, topical cyclosporine A, and therapeutic contact lenses. This case highlights a rare association between TSPK and CD, potentially explained by shared HLA genotypes, underscoring the need for further investigation into their immunogenetic link.
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