Evidence map›Paper›PMID 40196054›Full record

ArticleCureus2025

Acute Generalized Exanthematous Pustulosis Associated With Herpes Simplex Virus Reactivation Due to Cold Medicine: A Case Report and Review of the Literature.

Yoshihito Mima, Tsutomu Ohtsuka, Nobuhito Arakawa, Yoshimasa Nakazato, Yuta Norimatsu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yoshihito MimaDepartment of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, JPN.
Tsutomu OhtsukaDepartment of Dermatology, International University of Health and Welfare Hospital, Tochigi, JPN.
Nobuhito ArakawaDepartment of Respiratory Medicine, International University of Health and Welfare Hospital, Tochigi, JPN.
Yoshimasa NakazatoDepartment of Diagnostic Pathology, International University of Health and Welfare Hospital, Tochigi, JPN.
Yuta NorimatsuDepartment of Dermatology, International University of Health and Welfare, Narita Hospital, Narita, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a severe skin inflammation characterized by the sudden onset of numerous sterile, non-follicular pustules on an erythematous and edematous background, usually associated with fever. AGEP is commonly triggered by medications such as antibiotics. However, an association between AGEP and viral infections has also been reported recently. We report a case of a 70-year-old man who developed AGEP following the intake of an over-the-counter cold medicine in the context of herpes simplex virus (HSV) reactivation. Furthermore, we review three cases of AGEP associated with HSV infection. This report suggests HSV reactivation as a potential trigger for AGEP, emphasizing the need for caution when administering drugs to patients with HSV infection.

Indexed as

acute generalized exanthematous pustulosiscd4-positive t cellcold medicinedrug-induced eruptionsherpes simplex virus

Identifiers

PMID40196054
PMCPMC11973534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.