Evidence map›Paper›PMID 40196006›Full record

ArticleResearch square2025

Garrett W Cooper, Benjamin P Lee, Won Jun Kim, Yongdong Su, Victor Z Chen, Eliseo Salas, Xiaoping Yang, Robert E Lintner, Frederica Piccioni, Andrew O Giacomelli and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Garrett W CooperDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Benjamin P LeeDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-6937-2211
Won Jun KimDana-Farber Cancer Institute, Boston, MA, USA.
Yongdong SuDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-2092-8872
Victor Z ChenDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Eliseo SalasDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Xiaoping YangBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-6811-4915
Robert E LintnerBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-4379-7799
Frederica PiccioniBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1210-3210
Andrew O GiacomelliHumber Polytechnic, Toronto, ON, Canada.ORCID 0000-0003-2109-0458
Thomas P HowardDana-Farber Cancer Institute, Boston, MA, USA.
Pritha BagchiEmory Integrated Proteomics Core, Emory University, Atlanta, GA, USA.ORCID 0000-0001-7229-9476
Karen N ConneelyDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-1994-6934
David E RootBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-5122-861X
Bo LiangDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-5617-9228
William C HahnDana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-2840-9791
David U GorkinDepartment of Biology, Emory University, Atlanta, GA, USA.ORCID 0000-0003-4944-4107
Jaclyn A BiegelDepartment of Pathology, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Susan N ChiDana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0001-7753-878X
Andrew L HongDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0003-0374-1667

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Single-cell epigenomic phenotyping of IMPC-generated mouse lines lacking chromatin regulatorsR01HD102534 · NICHD · EMORY UNIVERSITY · PI GORKIN, DAVID USCHER · 2021 to 2025
$3.4M
Functional consequences of SMARCB1 variantsR01CA289761 · NCI · EMORY UNIVERSITY · PI Andrew L Hong · 2025 to 2026
$1.0M
The role of DPF2 stability in SMARCB1-deficient cancersF31CA278008 · NCI · EMORY UNIVERSITY · PI GARRETT COOPER · 2023 to 2026
$118k
NCATS NIH HHS UL1 TR002378NCI NIH HHS F31 CA278008NCI NIH HHS P30 CA138292NCI NIH HHS R01 CA289761NICHD NIH HHS R01 HD102534NIGMS NIH HHS T32 GM008490
6 · The paper itself

Abstract

Chromatin remodeling complexes, such as the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, play key roles in regulating gene expression by modulating nucleosome positioning. The core subunit SMARCB1 is essential for these functions, as it anchors the complex to the nucleosome acidic patch, enabling effective chromatin remodeling. While biallelic inactivation of

Identifiers

PMID40196006
PMCPMC11975040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.