Evidence map›Paper›PMID 40195995›Full record

ArticleResearch square2025

Assessing gut microbial provisioning of essential amino acids to host in a murine model with reconstituted gut microbiomes.

Paul Ayayee, Gordon Custer, Jonathan B Clayton, Jeff Price, Amanda Ramer-Tait, Thomas Larsen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Paul AyayeeDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.ORCID 0000-0003-2960-7378
Gordon CusterDepartment of Natural Sciences, University of Maryland Eastern Shore, Princess Anne, MD, USA.
Jonathan B ClaytonDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.ORCID 0000-0003-3709-3362
Jeff PriceDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Amanda Ramer-TaitDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0003-0950-7548
Thomas LarsenMax Planck Institute of Geoanthropology, Jena, Germany.ORCID 0000-0002-0311-9707

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
A Model of Antibiotic-induced Gut Dysbiosis and Depressive SymptomatologyK01OD030514 · OD · UNIVERSITY OF NEBRASKA OMAHA · PI Jonathan Brent Clayton · 2022 to 2026
$634k
NCI NIH HHS P30 CA036727NIGMS NIH HHS P20 GM103427NIH HHS K01 OD030514
6 · The paper itself

Abstract

Gut microbial essential amino acid (EAA) provisioning to mammalian hosts remains a critical yet poorly understood aspect of host-microbe nutritional interactions, with significant implications for human and animal health. To investigate microbial EAA contributions in mice with reconstituted gut microbiomes, we analyzed stable carbon isotopes (

Indexed as

auxotrophyEAA provisioninggerm-freeGut microbiomemousestable isotope

Identifiers

PMID40195995
PMCPMC11975013

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.