ArticleJournal of inflammation research2025
Study on the Clinical Efficacy of Combined Therapy with Minocycline Hydrochloride Ointment and Tinidazole for Chronic Periodontitis: Retrospective Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Wisdom across interfaces: Adhesion mechanism and application potential of wet-adhesive hydrogel in periodontal tissue.Bioactive materials · 2026Review
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3 authors.
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Abstract
Objective: To analyze the clinical efficacy of combined minocycline hydrochloride and tinidazole therapy for chronic periodontitis (CP). Methods: A retrospective analysis was conducted on clinical data from 93 CP patients admitted to our hospital from January 2021 to January 2023. All patients met the inclusion and exclusion criteria. They were divided into a control group (n=46) and an observation group (n=47). All patients received full-mouth ultrasonic debridement. On this basis, patients in the control group received weekly subgingival minocycline hydrochloride ointment (Sunstar Results: The results showed that the total effective rate of treatment in the observation group (91.49%) was significantly higher than that in the control group (73.91%) (P<0.05). The periodontal indicators (Plaque Index, Gingival Bleeding Index, Periodontal Pocket Depth), inflammatory factor indicators (C-reactive protein, Tumor Necrosis Factor-α, Interleukin-1β), Matrix Metalloproteinase-9 (MMP-9), and Secretory Immunoglobulin A (SIgA) levels of both groups decreased significantly after treatment. Moreover, these indicators in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination therapy of minocycline hydrochloride and tinidazole significantly improved the clinical efficacy for CP patients. Compared with minocycline hydrochloride alone, the addition of tinidazole further improved patients' periodontal health, reduced the inflammatory response and MMP-9, SIgA levels, and did not increase the risk of adverse reactions. This suggests good drug safety and clinical promotion value.
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