Evidence map›Paper›PMID 40195914›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Enhanced Laser-Induced Graphene Microfluidic Integrated Sensors (LIGMIS) for On-Site Biomedical and Environmental Monitoring.

Zachary T Johnson, Griffin Ellis, Cicero C Pola, Christopher Banwart, Abby McCormick, Gustavo L Miliao, Duy Duong, Jemima Opare-Addo, Harsha Sista, Emily A Smith and 3 more

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zachary T JohnsonDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Griffin EllisDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Cicero C PolaDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Christopher BanwartDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Abby McCormickDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Gustavo L MiliaoDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Duy DuongDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Jemima Opare-AddoDepartment of Chemistry, Iowa State University, Ames, IA, 50011, USA.
Harsha SistaDepartment of Aerospace Engineering, Iowa State University, Ames, IA, 50011, USA.
Emily A SmithDepartment of Chemistry, Iowa State University, Ames, IA, 50011, USA.
Hui HuDepartment of Aerospace Engineering, Iowa State University, Ames, IA, 50011, USA.
Carmen L GomesDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Jonathan C ClaussenDepartment of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.ORCID 0000-0001-7065-1077

Funding

Division of Civil, Mechanical and Manufacturing Innovation CMMI-2037026Division of Engineering Education and Centers EEC-2231632National Institute of Food and Agriculture 2021-67011-35130National Institute of Food and Agriculture 2021-67021-34457U.S. Department of Energy by Iowa State University DE-AC02-07CH11358
6 · The paper itself

Abstract

The convergence of microfluidic and electrochemical biosensor technologies offers significant potential for rapid, in-field diagnostics in biomedical and environmental applications. Traditional systems face challenges in cost, scalability, and operational complexity, especially in remote settings. Addressing these issues, laser-induced graphene microfluidic integrated sensors (LIGMIS) are presented as an innovative platform that integrates microfluidics and electrochemical sensors both comprised of laser-induced graphene. This study advances the LIGMIS concept by resolving issues of uneven fluid transport, increased hydrophobicity during storage, and sensor biofunctionalization challenges. Key innovations include Y-shaped reservoirs for consistent fluid flow, hydrophilic polyethyleneimine coatings to maintain wettability, and separable microfluidic and electrochemical components enabling isolated electrode nanoparticle metallization and biofunctionalization. Multiplexed electrochemical detection of the neonicotinoid imidacloprid and nitrate ions in environmental water samples yields detection limits of 707 nm and 10

Indexed as

Biosensing TechniquesEnvironmental MonitoringGraphiteLasersMicrofluidicsElectrochemical TechniquesNeonicotinoidsNitro CompoundsGraphiteimidaclopridNeonicotinoidsNitro Compoundsenvironmental monitoringlaser induced graphenemultiplexed biosensingopen microfluidicspoint‐of‐care diagnostics

Identifiers

PMID40195914
PMCPMC12366263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.