Evidence map›Paper›PMID 40195852›Full record

ArticleBritish journal of haematology2025

Myeloid neoplasm inspired intensive therapy in VEXAS syndrome: A single-centre experience.

Maël Heiblig, Adriana Plesa, Juliet Tantot, Yvan Jamilloux, Hélène Labussière-Wallet, Pierre Sujobert

Abstract readCase Reports
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maël HeibligService d'hématologie Clinique, Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France.ORCID https://orcid.org/0000-0003-1682-8657
Adriana PlesaService d'hématologie biologique, Hospices Civils de Lyon, Lyon, France.
Juliet TantotService d'anatomopathologie, Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France.
Yvan JamillouxService de Médecine Interne, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France.
Hélène Labussière-WalletService d'hématologie Clinique, Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France.
Pierre SujobertService d'hématologie biologique, Hospices Civils de Lyon, Lyon, France.ORCID https://orcid.org/0000-0002-9108-1162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is still no standard of care and unmet medical needs in refractory/advanced VEXAS (vacuoles in myeloid progenitors, E1 ubiquitin activating enzyme, X-linked, autoinflammatory manifestations and somatic) syndrome with or without associated haematological neoplasm. We report the clinical outcome of four multirefractory/advanced VEXAS patients treated with acute myeloid leukaemia-like therapeutic approaches. All patients responded to inflammatory/haematological VEXAS-related features, which were associated with measurable residual disease response (partial or complete). Prospective studies evaluating new and effective therapeutic strategies in order to reduce clonal burden in VEXAS patients are warranted.

Indexed as

Leukemia, Myeloid, AcuteHumansMyelodysplastic SyndromesSkin Diseases, GeneticUbiquitin-Activating EnzymesUBA1 protein, humanUbiquitin-Activating Enzymesacute leukaemiavenetoclaxVEXAS

Identifiers

PMID40195852
PMCPMC12166346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.