ArticleThe Journal of cell biology1985
Abrogation of cell surface expression of human class I transplantation antigens by an adenovirus protein in Xenopus laevis oocytes.
Article in The Journal of cell biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- The endoplasmic reticulum lumenal domain of the adenovirus type 2 E3-19K protein binds to peptide-filled and peptide-deficient HLA-A*1101 molecules.Journal of virology · 2005Article
- An HLA-B regulatory element binds a factor immunologically related to the upstream stimulation factor.Immunogenetics · 1993Article
- The single transmembrane segment of gp210 is sufficient for sorting to the pore membrane domain of the nuclear envelope.The Journal of cell biology · 1992Article
- A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- E3/19K from adenovirus 2 is an immunosubversive protein that binds to a structural motif regulating the intracellular transport of major histocompatibility complex class I proteins.The Journal of experimental medicine · 1990Article
- Role of early genes in pathogenesis of adenovirus pneumonia.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- A protein serologically and functionally related to the group C E3 14,700-kilodalton protein is found in multiple adenovirus serotypes.Journal of virology · 1990Article
- Role of early region 3 (E3) in pathogenesis of adenovirus disease.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Modification of the cell surface expression of histocompatibility antigens induced by the neurotoxin 2,5 hexanedione.Cell biology and toxicology · 1987Article
- Article
- Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein.The EMBO journal · 1986Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Class I transplantation antigens form complexes with a virus protein encoded in the early region E3 of the adenovirus-2 genome. The interaction between this viral glycoprotein, E19, and nascent human class I antigens has been examined by microinjecting purified mRNA into Xenopus laevis oocytes. Both E19 and the two class I antigen subunits, the heavy chain and beta 2-microglobulin (beta 2M), were efficiently translated. The heavy chains did not become terminally glycosylated, as monitored by endoglycosidase H digestion, and were not expressed on the oocyte surface unless they were associated with beta 2M. The E19 protein did not become terminally glycosylated, and we failed to detect this viral protein on the surface of the oocytes. Co-translation of heavy chain and E19 mRNA demonstrated that the two proteins associate intracellularly. However, neither protein appeared to be transported to the trans-Golgi compartment. Similar observations were made in adenovirus-infected HeLa cells. Heavy chains bound to beta 2M became terminally glycosylated in oocytes in the presence of low concentrations of E19. At high concentrations of the viral protein, no carbohydrate modifications and no cell surface expression of class I antigens were apparent. Thus, beta 2M and E19 have opposite effects on the intracellular transport of the heavy chains. These data suggest that adenovirus-2 may impede the cell surface expression of class I antigens to escape immune surveillance.
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