Trial reportRecent advances in inflammation & allergy drug discovery2025
Effect of Multi-trace Elements Supplementation on Biochemical Markers and Postoperative Outcome in Patients Undergoing Elective Cardiac Surgery.
Trial report in Recent advances in inflammation & allergy drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCoronary Artery Bypass Graft (CABG) surgery is employed to increase the lifespan of patients with Coronary Artery Disease (CAD). The low serum levels of essential elements have a negative effect on patients undergoing CABG.
objectiveThis clinical trial aimed to investigate the effect of trace elements supplements on postoperative outcomes after coronary artery bypass graft.
methodsTwo hundred patients underwent on-pump CABG to randomly receive either Addamel
resultsIn the supplemented group, the plasma levels of Cu and Mn increased by day 3, and plasma hs-CRP increased by day 1 in both groups, but it decreased in patients who received trace elements supplementation on day 2. The Addamel group had a lower mortality rate, though the difference did not reach a significant level. There was a significant negative correlation observed between plasma Zn level and 30-day mortality, along with another significant negative link between plasma CRP level before operation and Sepsis-related Organ Failure Assessment (SOFA) score. Other measured parameters were similar between the intervention and placebo groups.
conclusionThe patients undergoing CABG appeared to benefit from trace element supplementation. A brief period of Addamel administration following CABG could prevent a decrease in the serum concentration of trace elements and reduce the circulating plasma CRP.
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