Evidence map›Paper›PMID 40195576›Full record

ArticleDrug delivery2025

Preparation, quality evaluation and preliminary pharmacokinetic-pharmacodynamic studies of synephrine dry powder inhaler.

Jiming Ke, Shenao Li, Miaomiao Zi, Jing Zhang, Shan Huang, Wenhui Luo, Hailun Han, Jiwen Zhang, Can Peng

Abstract read
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiming KeSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Shenao LiSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Miaomiao ZiSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Jing ZhangSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Shan HuangSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Wenhui LuoSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Hailun HanSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Jiwen ZhangSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Can PengSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is a lung disease characterized by pulmonary edema caused by an excessive inflammatory response within the lungs and disruption of the alveolar capillary barrier, with a high morbidity and mortality rate in critically ill patients. Dry powder inhalers (DPI) are an effective way of administering medication to improve efficacy, and inhalation administration not only improves efficacy but also increases the bioavailability of the drug. Synephrine, a natural ingredient derived from the fruit of the citrus plant in the

Indexed as

Acute Lung InjuryAnti-Inflammatory AgentsDry Powder InhalersSynephrineAdministration, InhalationAnimalsAntioxidantsBiological AvailabilityMaleMiceOxidative StressParticle SizePowdersRatsRats, Sprague-DawleyAnti-Inflammatory AgentsAntioxidantsPowdersSynephrineacute lung injurydry powder inhalerin vivo and in vitro efficacypharmacokineticsSynephrine

Identifiers

PMID40195576
PMCPMC11983587

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.