Evidence map›Paper›PMID 40195556›Full record

ArticleNPJ digital medicine2025

Telehealth virtual reality intervention reduces chronic pain in a randomized crossover study.

Luana Colloca, Anna Han, Rachel Massalee, Nandini Raghuraman, Rachel L Cundiff-O'Sullivan, Giancarlo Colloca, Yang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luana CollocaDepartment of Pain Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA. colloca@umaryland.edu.
Anna Han *Department of Pain Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA.
Rachel Massalee *Department of Pain Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA.
Nandini RaghuramanDepartment of Pain Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA.
Rachel L Cundiff-O'SullivanDepartment of Pain Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA.
Giancarlo CollocaDepartment of Computer & Information Sciences, Information Technology PhD Program, Towson University, Towson, MD, USA.
Yang WangDepartment of Pain Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA. yang.wang@umaryland.edu.

Funding

Neural correlates of hypoalgesia driven by observationR01AT010333 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI COLLOCA, LUANA · 2019 to 2023
$3.7M
Neural Mechanisms of Immersive Virtual Reality in Chronic PainR01AT011347 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI Luana Colloca · 2021 to 2026
$3.2M
NCCIH NIH HHS R01AT01033NCCIH NIH HHS R01 AT010333NCCIH NIH HHS R01 AT011347
6 · The paper itself

Abstract

The efficacy of telehealth Virtual Reality (VR) for chronic pain, a promising digital intervention, remains underexplored due to methodological challenges. In a 5-week crossover trial, we compared VR to matched audio content control in individuals with chronic pain. VR significantly reduced pain intensity, anxiety, and pain interference while improving mood and sleep quality. Findings highlight the potential of telehealth-based VR for addressing real-world challenges in managing chronic pain. ISRCTN12473220 (07/18/2023).

Identifiers

PMID40195556
PMCPMC11976909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.