Evidence map›Paper›PMID 40195488›Full record

ArticleScientific reports2025

Persistent neutrophilic inflammation is associated with delayed toxicity of phenylarsine oxide in lungs.

Nilda C Sanchez, Gopikrishnan Mani, Joanna I Nowak, Carlin Jones, Young-Il Kim, Nirmal S Sharma, Jaroslaw W Zmijewski, Ranu Surolia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nilda C SanchezDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Gopikrishnan ManiDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Joanna I NowakDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Carlin JonesDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Young-Il KimDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Nirmal S SharmaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jaroslaw W ZmijewskiDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Ranu SuroliaDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. ranusurolia@uabmc.edu.

Funding

AMPK in the Development and Resolution of Lung FibrosisR01HL139617 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Victor J. Thannickal, Jaroslaw Waldemar Zmijewski · 2019 to 2026
$4.4M
Environmental Cadmium, persistent inflammation and airways diseaseR01ES035072 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Ranu Surolia · 2023 to 2026
$1.8M
BLRD VA I01 BX003056NHLBI NIH HHS R01 HL139617NIEHS NIH HHS R01 ES035072NIEHS NIH HHS R01ES035072NIH/NHLBI 2R01HL139617The department of defense, united states HT9425-24-1-0304
6 · The paper itself

Abstract

Phenyl arsine oxide (PAO) is a vesicant, similar to Lewisite, a potential chemical warfare agent and an environmental contaminant. PAO-induced skin burns can trigger acute organ injury, including lungs. We have recently demonstrated that PAO burns can have delayed toxicity, although the specific mechanism/s remain to be determined. A single cutaneous exposure to PAO resulted in inflammatory acute lung injury at 6 and 24 h. While acute injury subsiding by 1 week, we observed a significant airway remodeling at 10 weeks post-PAO exposure. The mechanism of prolonged PAO toxicity was associated with the influx of neutrophils that produced harmful neutrophil extracellular traps (NETs). We demonstrated that the crosstalk between NET deployments and expression of IL-33, a pro-remodeling mediator was associated with the development of peribronchial fibrosis. In summary, these results suggest that a single cutaneous exposure to PAO causes the acute inflammatory phase followed by NETs/IL-33 feed forward signaling implicated for the persistent neutrophil influx and NETs formation resulting in airway remodeling.

Indexed as

Acute Lung InjuryArsenicalsInflammationLungNeutrophilsAirway RemodelingAnimalsChemical Warfare AgentsExtracellular TrapsInterleukin-33MiceArsenicalsChemical Warfare AgentsInterleukin-33Airway remodelingArsenicalsIL-33Neutrophil extracellular trapsPersistent inflammationPhenyl Arsine oxide

Identifiers

PMID40195488
PMCPMC11976910

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.