Evidence map›Paper›PMID 40195472›Full record

ReviewThe Journal of antibiotics2025

Biosynthesis of antibiotics with sulfonamide and azaindane moieties.

Takayoshi Awakawa

Abstract readReview
PubMed Publisher
In one paragraph

Review in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Takayoshi AwakawaRIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan. takayoshi.awakawa@riken.jp.ORCID 0000-0003-2575-3175

Funding

MEXT | Japan Science and Technology Agency (JST) JPMJFR2301MEXT | Japan Society for the Promotion of Science (JSPS) 21H02636MEXT | Japan Society for the Promotion of Science (JSPS) 22H05123
6 · The paper itself

Abstract

As research into the biosynthesis of natural products has matured, the biosynthetic pathways of common skeletons have been identified one after another, and attention is now being focused on research into the biosynthetic machineries of compounds with rare skeletons. Such research has the potential for leading to the discovery of new biosynthetic enzymes and artificial biosynthesis of unnatural compounds. In this study, I introduce the biosynthetic research on altemicidin, SB-203207, and SB-203208, which are rare natural products containing sulfonamide and azaindane skeletons. Further, self-resistance gene mining, the biosynthetic machineries of aminoacyl transferases, the synthesis of sulfonamides and azaindanes, and the structural basis and reaction mechanism of the biosynthetic enzyme SzbP, which uses beta-nicotinamide adenine dinucleotide (β-NAD) and S-adenosylmethionine (SAM) as substrates to create the first intermediate in the biosynthesis, are discussed in detail.

Indexed as

Anti-Bacterial AgentsAza CompoundsSulfonamidesBiological ProductsBiosynthetic PathwaysAnti-Bacterial AgentsAza CompoundsBiological ProductsSulfonamides

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.