Portal hypertension aggravates Helicobacter pylori induced liver injury in mice via activating pyroptosis pathway.

JiKe Hu, Lei Gao, Ewetse Paul Maswikiti, Xuemei Li, Baohong Gu, Yang Yu, Haiyuan Li, Hao Chen

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Predicting short-term mortality in severe cirrhosis: An interpretable machine learning model integrating routine clinical indicators.PloS one · 2026
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8 authors.

JiKe Hu *The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.

Lei Gao *The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.

Ewetse Paul MaswikitiThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.

Xuemei LiThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.

Baohong GuThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.

Yang YuThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.

Haiyuan LiThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.

Hao ChenDepartment of Surgical Oncology, The Second Hospital of Lanzhou University, Lanzhou, China. ery_chenh@lzu.edu.cn.

Funding

Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital CY2023-ZD-01Gansu Province Innovation Driven Assistance Project GXH20230817-14Key Project of Science and Technology in Gansu province 22ZD6FA054Key Talents Project of Gansu Province 2019RCXM020Medical Innovation and Development Project of Lanzhou University lzuyxcx-2022-160National Natural Science Foundation of China 82160129Science and Technology Project of Chengguan District of Lanzhou City 2020SHFZ0039The Gansu Province Postgraduate Innovation Star Program 2025CXZX-115

6 · The paper itself

Abstract

In recent years, it has been discovered that the pathogenic effect of Helicobacter pylori (H. pylori) is not only limited to the gastroduodenal region, but also plays a certain role in the occurrence and development of liver diseases. The aim of this study is to ascertain the existence of Helicobacter pylori translocation, investigate whether it leads to liver injury and its potential mechanism and examine whether portal hypertension exacerbates liver damage caused by H. pylori translocation. Twenty four male SPF C57BL/6J mice were divided into four groups (6 in each group): (1) control group (Normal); (2) portal hypertension group (PHT); (3) H. pylori infected group (Hp); (4) H. pylori and Portal hypertension group (Hp and PHT). The histopathological changes of the liver and gastric tissues were measured by HE staining and immunohistochemistry (IHC); ALT, AST, IL-6 and INF-γ was measured by ELISA; Western blot detected the expression of pyroptotic proteins in the liver. The pro-inflammatory mediators and liver function indexes of mice in Hp group, Hp and PHT group were higher than those in the normal and PHT group. In addition, the liver inflammatory cell infiltration and ballooning of the two groups of mice were more severe than those in the normal group and PHT group, Hp and PHT group were more severe; Hp group, Hp and PHT group mice liver tissues activated the pyroptotic process through NLRP3 inflammasome, which eventually led to cell damage. Post mice infection by H. pylori, H. pylori will translocate to the liver, and induce liver injury by aggravating inflammation and promoting pyroptosis. Moreover, when portal hypertension occurs, it promotes the displacement of H. pylori, thereby aggravating liver injury.

Indexed as

Helicobacter InfectionsHelicobacter pyloriHypertension, PortalLiver DiseasesPyroptosisAnimalsDisease Models, AnimalLiverMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinSignal TransductionNLR Family, Pyrin Domain-Containing 3 ProteinHelicobacter pyloriLiver injuryNLRP3Portal hypertensionPyroptosis

Identifiers

PMID40195372

DOI10.1038/s41598-025-96132-1

PMCPMC11977220

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.