ArticleScientific reports2025
The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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9 authors.
Funding
Abstract
Long-lasting insecticidal nets and indoor residual sprays have played a major role in significantly reducing the burden of malaria. However, the management of mosquitoes resistant to current insecticides continues to be challenging. A promising new strategy is drug-based vector control where drugs are administered to vector hosts (human/animal), which renders the host blood toxic to mosquitoes-thereby reducing mosquito lifespan, fecundity and onward transmission of pathogens. Afoxolaner, fluralaner, and lotilaner are isoxazoline derivatives widely used as systemic insecticides for ectoparasite control in companion animals. Here, the mosquitocidal activity of these compounds against Anopheles gambiae s.s, Anopheles coluzzii, Aedes aegypti, and Anopheles funestus mosquitoes was evaluated. The effect of antibiotic treatment and different carbohydrates in artificial nectar meals on isoxazoline activity was also investigated. All isoxazolines tested showed rapid killing with little difference in susceptibility between different species and genera of mosquitoes. Fluralaner showed the most potent mosquitocidal effects with IC
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