ArticleNature communications2025
MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Clinical Soma and Neurite Density Imaging (SANDI): Translational Microstructure Mapping on Clinical 3T MRI Scanners.Magnetic resonance in medicine · 2026Article
- Comparative Systematic Analysis of Gray Matter Biophysical Models on a Public Dataset.Magnetic resonance in medicine · 2026Article
- Invisible neuronal damage in stroke-free, asymptomatic chronic middle cerebral artery occlusion: evidence from soma and neurite density imaging.European radiology · 2026Article
- Demographics change the relationships between socioeconomic status, white matter network organization, and cognition in children.Developmental cognitive neuroscience · 2026Article
- Congenital blindness reduces myelination in human visual cortex.Science advances · 2026Article
- Microstructural variation of hippocampal substructures across childhood and adolescence quantified with high-gradient diffusion MRI.Communications biology · 2026Article
- Analysis of cortical dysplasias using b-tensor encoding diffusion MRI in an animal model.PloS one · 2026Article
- Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism.Translational psychiatry · 2025Review
- Microstructural maturation of the adult mouse brain.Communications biology · 2025Article
- Cellular basis for cortical network aging in primates.bioRxiv : the preprint server for biology · 2025Article
- The Effect of Physical Activity Interventions on Executive Function in Overweight and Obese Adults: A Systematic Review.Biomedicines · 2024Review
- The developing hippocampus: Microstructural evolution through childhood and adolescence.bioRxiv : the preprint server for biology · 2024Article
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Abstract
Neuroanatomical changes to the cortex during adolescence have been well documented using MRI, revealing ongoing cortical thinning and volume loss. Recent advances in MRI hardware and biophysical models of tissue informed by diffusion MRI data hold promise for identifying the cellular changes driving these morphological observations. Using ultra-strong gradient MRI, this study quantifies cortical neurite and soma microstructure in typically developing youth. Across domain-specific networks, cortical neurite signal fraction, attributed to neuronal and glial processes, increases with age. The apparent soma radius, attributed to the apparent radius of glial and neuronal cell bodies, decreases with age. Analyses of two independent post-mortem datasets reveal that genes increasing in expression through adolescence are significantly enriched in cortical oligodendrocytes and Layer 5-6 neurons. In our study, we show spatial and temporal alignment of oligodendrocyte cell-type gene expression with neurite and soma microstructural changes, suggesting that ongoing cortical myelination processes drive adolescent cortical development.
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