Evidence map›Paper›PMID 40195325›Full record

ArticleCell death discovery2025

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand.

Jung Kwon Lee, Karl Riabowol, Xidi Wang, Ki-Young Lee

Abstract read
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jung Kwon LeeArnie Charbonneau Cancer and Alberta Children's Hospital Research Institutes, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0003-0940-2930
Karl RiabowolArnie Charbonneau Cancer and Alberta Children's Hospital Research Institutes, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-5318-2536
Xidi WangCentral Laboratory of the Medical Research Center, The First Affiliated Hospital of Ningbo University, Ningbo, PR China.ORCID http://orcid.org/0000-0001-7924-5120
Ki-Young LeeArnie Charbonneau Cancer and Alberta Children's Hospital Research Institutes, Department of Cell Biology & Anatomy, University of Calgary, Calgary, AB, Canada. kyleecal1957@gmail.com.ORCID http://orcid.org/0000-0002-5387-2692

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-174983
6 · The paper itself

Abstract

L-asparaginase is an indispensable chemotherapeutic drug for patients with acute lymphoblastic leukemia (aLL), a life-threatening lymphoid neoplasm and the prime cause of cancer death among children. Previously, we reported that L-asparaginase kills aLL cells via an excessive rise in [Ca

Identifiers

PMID40195325
PMCPMC11977020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.