Evidence map›Paper›PMID 40195288›Full record

ArticleUnited European gastroenterology journal2025

Disorders of the gut-brain interaction among European people with obesity: Prevalence and burden of compatible symptoms.

Chloé Melchior, Jóhann P Hreinsson, Jan Tack, Jutta Keller, Qasim Aziz, Olafur S Palsson, Shrikant I Bangdiwala, Ami D Sperber, Magnus Simrén, Jean-Marc Sabaté

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chloé MelchiorDepartment of Gastroenterology, Univ Rouen Normandie, INSERM, ADEN UMR1073 "Nutrition, Inflammation and Microbiota-Gut-Brain Axis", CHU Rouen, CIC-CRB 1404, Rouen, France.ORCID 0000-0002-8146-1540
Jóhann P HreinssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-0078-3063
Jan TackTranslational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium.
Jutta KellerDepartment of Internal Medicine, Israelitic Hospital Hamburg, Hamburg, Germany.ORCID 0000-0002-5884-1115
Qasim AzizCentre for Neuroscience, Surgery and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Olafur S PalssonCenter for Functional GI and Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Shrikant I BangdiwalaDepartment of Health Research Methods, Evidence and Impact, and Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Ami D SperberFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID 0000-0002-7634-3689
Magnus SimrénDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jean-Marc SabatéDepartment of Gastroenterology, Hôpital Avicenne, AP-HP, Sorbonne Paris Nord, Bobigny, France.

Funding

AllerganIronwood Pharmaceuticals, Incorporatedromanian society of neurogastroenterologyShireTakeda Pharmaceutical Company
6 · The paper itself

Abstract

introductionThe prevalence of disorders of the gut-brain interaction (DGBI) among people with obesity in the general population is unknown. Our aim was to assess the prevalence of DGBI among obese subjects in the general population in comparison with normal or overweight subjects, as well as exploring factors associated with DGBI in obesity in Europe.

methodsWe included subjects who completed the internet-based survey of the Rome Foundation Global Epidemiology study in 11 European countries. Obesity was defined as a BMI>30 kg/m

resultsWe included 20,117 participants in our analysis. The prevalence of obesity was 17.8% (95% CI 17.3, 18.4), with 12.6%, 3.7% and 1.6% in obesity classes 1, 2 and 3, respectively. The prevalence of any DGBI was 44.2% in the obese group versus 39.6% in the normal or overweight group (OR = 1.20 (1.12, 1.30)), with all DGBI being more prevalent in the obese versus normal or overweight group, with the exception for functional constipation where the opposite pattern was seen. Female sex, higher level of psychological distress and more severe non-GI somatic symptoms were seen in the group with DGBI associated with obesity.

conclusionsSymptoms compatible with DGBI are common among European people with obesity in the general population and are linked with certain demographic and disease-related factors. This should be acknowledged in the management of patients with obesity.

Indexed as

Brain-Gut AxisGastrointestinal DiseasesObesityAdultAgedBody Mass IndexCross-Sectional StudiesEuropeEuropean PeopleFemaleHumansMaleMiddle AgedOverweightPrevalenceQuality of LifeconstipationDGBIdyspepsiafunctionalhealthcare accessirritable bowel syndromeoverweightquality of lifeRomesex

Identifiers

PMID40195288
PMCPMC12269724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.