Evidence map›Paper›PMID 40195216›Full record

ArticleMolecular neurobiology2025

GLUT1 and Cerebral Glucose Hypometabolism in Human Focal Cortical Dysplasia Is Associated with Hypermethylation of Key Glucose Regulatory Genes.

Chaitali Ghosh, Rosemary Westcott, David Skvasik, Ishant Khurana, Jean Khoury, Ingmar Blumcke, Assam El-Osta, Imad M Najm

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Chaitali GhoshNeurovascular Research, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. GHOSHC@ccf.org.ORCID http://orcid.org/0000-0003-4078-0278
Rosemary WestcottNeurovascular Research, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
David SkvasikNeurovascular Research, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Ishant KhuranaEpigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, Melbourne, Australia.
Jean KhouryEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Ingmar BlumckeInstitute of Neuropathology, University Hospitals Erlangen, Erlangen, Germany.
Assam El-OstaEpigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, Melbourne, Australia.
Imad M NajmEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

Cytochrome P450-mediated drug interactions at the human blood-brain barrierR01NS095825 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI GHOSH, CHAITALI · 2017 to 2021
$1.7M
Molecular Mechanism of Glucocorticoid Receptor, Cytochrome P450, and P-Glycoprotein Axis on Drug Regulation at the Blood-Brain Barrier in Epilepsy with Focal Cortical DysplasiaR01NS137230 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Chaitali Ghosh · 2025 to 2026
$863k
NINDS NIH HHS R01 NS095825NINDS NIH HHS R01NS095825NINDS NIH HHS R01 NS137230
6 · The paper itself

Abstract

Focal cortical dysplasia (FCD) is a significant etiological factor in drug-resistant epilepsy, linked with disturbances in neurovascular metabolism. Our study investigated regulation of glucose-transporter1 (GLUT1) and cerebral hypometabolism within FCD subtypes. Surgically excised human brain specimens underwent histopathological categorization. A subset of samples was assessed for DNA methylation changes of glucose metabolism-related genes. We evaluated GLUT1, vascular endothelial growth factor alpha (VEGFα), monocarboxylate-transporter (MCT2), and mammalian target of rapamycin (mTOR) expression, measured glucose-lactate concentrations, and established correlations with patients' demographic and clinical profiles. Furthermore, we investigated the impact of DNA methylation inhibitor decitabine and hypometabolic condition on the uptake of [

Indexed as

DNA MethylationGlucoseGlucose Transporter Type 1Malformations of Cortical DevelopmentAdolescentAdultBrainChildChild, PreschoolEndothelial CellsFemaleFocal Cortical DysplasiaHumansMaleMiddle AgedTOR Serine-Threonine KinasesGlucoseGlucose Transporter Type 1SLC2A1 protein, humanTOR Serine-Threonine KinasesAngiogenic markerBiomarkerDNA methylationDrug-resistant epilepsyFocal cortical dysplasiaGlucose transporter-1Neurotrophic factors

Identifiers

PMID40195216
PMCPMC12289428

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.