Evidence map›Paper›PMID 40195192›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Efficacy and role of indocyanine green angiography in thyroidectomy: a systematic review and meta-analysis.

Van Cuong Nguyen, Chang Myeon Song, Yong Bae Ji, Jae Kyung Myung, Jin Hyeok Jeong, Kyung Tae

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Van Cuong NguyenDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni- ro, Seongdong-gu, Seoul, 04763, Republic of Korea.ORCID http://orcid.org/0000-0002-0836-3020
Chang Myeon SongDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni- ro, Seongdong-gu, Seoul, 04763, Republic of Korea.ORCID http://orcid.org/0000-0001-5267-0135
Yong Bae JiDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni- ro, Seongdong-gu, Seoul, 04763, Republic of Korea.ORCID http://orcid.org/0000-0002-0182-7865
Jae Kyung MyungDepartment of Pathology, College of Medicine, Hanyang University, Seoul, 04763, Republic of Korea.ORCID http://orcid.org/0000-0001-9612-5323
Jin Hyeok JeongDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni- ro, Seongdong-gu, Seoul, 04763, Republic of Korea.ORCID http://orcid.org/0000-0001-8424-3998
Kyung TaeDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni- ro, Seongdong-gu, Seoul, 04763, Republic of Korea. kytae@hanyang.ac.kr.ORCID http://orcid.org/0000-0002-0382-2072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study evaluates the role and effectiveness of indocyanine green (ICG) angiography in conventional thyroidectomy, comparing its outcomes with those of the naked-eye (NE) technique.

methodsA comprehensive literature search was conducted in PubMed, EMBASE, and the Cochrane Library databases through November 2024. Meta-analyses were performed on the selected studies. We compared the rates of parathyroid gland (PG) identification, autotransplantation, hypoparathyroidism, hypocalcemia, and postoperative levels of intact parathyroid hormone (iPTH) and calcium between the ICG and NE groups.

resultsWe analyzed 29 studies involving 2,393 thyroidectomies. The PG identification rate was significantly higher in the ICG group at 84.7% (95% CI: 77.5-90.0%) than in the NE group (OR = 1.49, 95% CI: 1.26-1.79). Additionally, the rate of parathyroid autotransplantation was higher in the ICG group (OR = 2.18, 95% CI: 1.56-3.03). The transient hypoparathyroidism rate in the ICG group was 11.0% (95% CI: 5.3-21.5%), which was slightly lower than that in the NE group, although the difference was not statistically significant. Conversely, the transient hypocalcemia rate was significantly lower in the ICG group at 13.2% (95% CI: 8.6-19.6%) than in the NE group (OR = 0.50, 95% CI: 0.30-0.85). No significant differences were observed between the two groups in 1-day postoperative iPTH or calcium levels.

conclusionThis meta-analysis demonstrates the superior efficacy of ICG angiography over the NE technique during thyroidectomy. ICG angiography resulted in a higher PG identification rate and significantly reduced postoperative transient hypocalcemia compared to those in the NE approach.

Indexed as

AngiographyColoring AgentsIndocyanine GreenParathyroid GlandsThyroidectomyHumansHypocalcemiaHypoparathyroidismPostoperative ComplicationsColoring AgentsIndocyanine GreenIndocyanine green angiographyMeta-analysisParathyroid glandSystematic reviewThyroid cancer

Identifiers

PMID40195192

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.