Evidence map›Paper›PMID 40195077›Full record

ArticleMagnetic resonance in medicine2025

MR-Cavitation Dynamics Encoded (MR-CaDE) imaging.

Dinank Gupta, Tarana P Kaovasia, Steven P Allen, Jon-Fredrik Nielsen, Timothy L Hall, Zhen Xu, Douglas C Noll

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. MR-Cavitation Dynamics Encoded (MR-CaDE) imaging.Magnetic resonance in medicine · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dinank GuptaBiomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-7496-1056
Tarana P KaovasiaBiomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-1786-8215
Steven P AllenElectrical and Computer Engineering, Brigham Young University, Provo, Utah, USA.ORCID 0000-0003-4778-8168
Jon-Fredrik NielsenBiomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-2058-3579
Timothy L HallBiomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4867-2856
Zhen XuBiomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-0262-3044
Douglas C NollBiomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0983-3805

Funding

Transcranial Magnetic Resonance guided Histotripsy (tcMRgHt)R01EB028309 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, ZHEN · 2019 to 2022
$2.4M
Upgrade for MRI Instrument for Functional Brain ImagingS10OD026738 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOLL, DOUGLAS C · 2019 to 2019
$1.8M
Transcranial MRI- and Ultrasound- guided histotripsy (tcMR-USgHt) systemR01EB037129 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Zhen Xu · 2025 to 2026
$1.2M
Focused Ultrasound FoundationNIBIB NIH HHS R01 EB028309NIBIB NIH HHS R01EB028309NIBIB NIH HHS R01 EB037129NIH HHS S10 OD026738
6 · The paper itself

Abstract

purposeTo develop methods for dynamic cavitation monitoring of a non-invasive ultrasound mechanical ablation technology (histotripsy) in the brain and test its feasibility for treatment monitoring in ex-vivo brain in a human MRI scanner.

methodsA Gradient Echo (GRE) pulse sequence was modified with a bipolar gradient to perform MR-Cavitation Dynamics Encoded (MR-CaDE) imaging. Cavitation generated by histotripsy sonication was monitored using MR-CaDE imaging in ex-vivo bovine brain tissues on a

resultsThe MR-CaDE imaging pulse sequence was used to perform treatment monitoring of cavitation generated by histotripsy with a temporal resolution of

conclusionThis work demonstrated the feasibility of the MR-CaDE pulse sequence, which can be used to monitor cavitation events in the brain generated by histotripsy.

Indexed as

BrainMagnetic Resonance ImagingAnimalsCattleHumansbraincavitationfocused ultrasoundgradient echohistotripsy

Identifiers

PMID40195077
PMCPMC12137772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.