ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Directional Macrocycle Transport, Release, and Recapture Enabled by a Rotaxane Transporter.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
A transporter for a directional macrocycle transport, release, and recapture was constructed. This was achieved using a rotaxane featuring a dibenzo-24-crown-8 macrocycle, dibenzylammonium (DBA)/methyl triazolium (MTA) stations on the thread and anthracene/triisopropylsilyl-acetylene stoppers, respectively. In the protonated rotaxane, the macrocycle primarily resides on the DBA station, followed by directional shuttling to the MTA station upon treatment with base. Addition of fluoride as an additional chemical input cleaves the triisopropylsilyl stopper, leading to release of the macrocycle and the half-thread into solution. The released macrocycle can be recaptured by protonation, and the mechanical bond can be reestablished via CuAAC click reaction, enabled by the terminal acetylene unit on the half-thread. This generates an elongated second-generation rotaxane transporter, which was used for a second cycle of directional macrocycle transport and release, proving the possibility of an iterative operation of the rotaxane-transporter in this molecular design.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.