ArticleACS biomaterials science & engineering2025
Enhancing Viability in Static and Perfused 3D Tissue Constructs Using Sacrificial Gelatin Microparticles.
Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A one-step volumetric biofabrication platform for complex hydrogel-based hollow biomaterials.Materials today. Bio · 2026Article
- Harnessing inter-spheroid spacing and structural connectivity to direct collective cell migration and host vessel integration in 3D engineered tissue.Materials today. Bio · 2026Article
- Review
- Translational Progress and Clinical Challenges in Bioengineered Bone and Joint Repair.Biomedicines · 2026Review
- Facile and Green Fabrication of Porous Hydrogels Based on Gelatin Microsphere Porogens for 3D Immune Cell Culture.Gels (Basel, Switzerland) · 2026Article
- Modeling of Biomechanical and Functional Parameters of Hydrogel-Cell Composites Fabricated by 3D Bioprinting Using AI-Supported Approach.Materials (Basel, Switzerland) · 2026Article
- Prospects and Limitations of Bioprinting in Studying Human Cells' Responses to Extreme Environments.Bioengineering (Basel, Switzerland) · 2026Article
- Improving Diffusion in Collagen Hydrogels for 3D Culture of Rat Cardiac or Dermal Fibroblasts via Magnetically Actuated Vibrating Microparts.Gels (Basel, Switzerland) · 2026Article
- Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels.Device · 2026Article
- Formulation Progress, Challenges, and Perspectives of Anti-Inflammatory Natural Products.Drug design, development and therapy · 2026Review
- Zone-inspired hydrogel constructs promote spatially controlled chondrogenesis for osteochondral regeneration.Scientific reports · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Current limitations in engineered tissues arise from the inability to provide sufficient nutrients to cells deep within constructs, restricting their viability. This study focuses on enhancing diffusion by creating a microporous microenvironment using gelatin microparticles within collagen scaffolds. By leveraging the FRESH (Freeform Reversible Embedding of Suspended Hydrogels) 3D bioprinting technique, gelatin microparticles are utilized both as a support material and as a thermoresponsive porogen to establish interconnected pores. The results indicate that scaffolds with 75% porosity significantly increase diffusion rates and cell viability, extending beyond the conventional ∼200 μm limit. Additionally, integrating vascular-like channels with porous scaffolds and applying perfusion improved nutrient transport, leading to enhanced cell survival in larger constructs. This combination of microporosity and perfusion represents a promising approach to create thicker tissues without necrotic regions, potentially paving the way for scalable tissue engineering applications. The findings suggest that optimizing pore sizes and scaffold perfusion can bridge the gap between rapid tissue formation and slower vascularization processes, enabling the future development of functional tissue constructs at clinically relevant scales.
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