Evidence map›Paper›PMID 40194719›Full record

ArticleEnvironmental toxicology and pharmacology2025

Effects of lithium on mortality and metabolite profiles in Drosophila lithium-inducible SLC6 transporter mutants.

Junko Kasuya, Karina Kruth, Dongkeun Lee, Jong Sung Kim, Aislinn Williams, Toshihiro Kitamoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental toxicology and pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junko KasuyaDepartment of Anesthesia, Carver College of Medicine, University of Iowa, 1-316 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA.
Karina KruthDepartment of Psychiatry, Carver College of Medicine, University of Iowa, 2326 Pappajohn Biomedical Discovery Building, 169 Newton Road, Iowa City, IA 52242, USA.
Dongkeun LeeDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa S357 College of Public Health Building, 145 North Riverside Drive, Iowa City, IA 52242, USA.
Jong Sung KimDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa S357 College of Public Health Building, 145 North Riverside Drive, Iowa City, IA 52242, USA.
Aislinn WilliamsDepartment of Psychiatry, Carver College of Medicine, University of Iowa, 2326 Pappajohn Biomedical Discovery Building, 169 Newton Road, Iowa City, IA 52242, USA.
Toshihiro KitamotoDepartment of Anesthesia, Carver College of Medicine, University of Iowa, 1-316 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA. Electronic address: toshi-kitamoto@uiowa.edu.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Cerebellar metabolism, neural circuits, and symptoms in bipolar disorderR01MH111578 · NIMH · UNIVERSITY OF IOWA · PI VINCENT A MAGNOTTA, John A Wemmie · 2017 to 2026
$5.7M
The Iowa Neuroscience Specialty Program in Research Education (INSPIRE)T32MH019113 · NIMH · UNIVERSITY OF IOWA · PI HANNA E STEVENS, John A Wemmie · 1991 to 2026
$5.6M
Suicidality in Bipolar and Major Depression DisordersR01MH125838 · NIMH · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A, WEMMIE, JOHN A · 2022 to 2024
$2.3M
Studies of genes involved in the lithium responsive neurological processesR01MH085081 · NIMH · UNIVERSITY OF IOWA · PI KITAMOTO, TOSHIHIRO · 2009 to 2013
$1.6M
Suicidality in Bipolar and Major Depression DisordersRF1MH125838 · NIMH · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A, WEMMIE, JOHN A · 2025 to 2025
$1.4M
Protective roles of the lithium-inducible SLC6 transporter in lithium's adverse effects: Insights from Drosophila geneticsR21NS145387 · NINDS · UNIVERSITY OF IOWA · PI KITAMOTO, TOSHIHIRO · 2025 to 2025
$428k
Identification of genes involved in the lithium-responsive neurological processR03MH078271 · NIMH · UNIVERSITY OF IOWA · PI KITAMOTO, TOSHIHIRO · 2006 to 2007
$145k
NIEHS NIH HHS P30 ES005605NIMH NIH HHS R01 MH085081NIMH NIH HHS R01 MH111578NIMH NIH HHS R01 MH125838NIMH NIH HHS R03 MH078271NIMH NIH HHS RF1 MH125838NIMH NIH HHS T32 MH019113NINDS NIH HHS R21 NS145387
6 · The paper itself

Abstract

Lithium has long been the primary treatment for bipolar disorder and shows promise for managing other neurological and psychiatric conditions. We previously identified the Lithium-inducible SLC6 transporter (List) in Drosophila melanogaster as a gene significantly upregulated in response to lithium chloride supplementation. List encodes a putative amino acid transporter belonging to the Na⁺-dependent solute carrier family 6. Here, we show that List is expressed in the Malpighian tubules, glia, and hindgut. RNA interference-mediated List knockdown in the Malpighian tubules drastically increases lithium-induced mortality. Additionally, List loss-of-function mutants (List

Indexed as

Amino Acid Transport SystemsDrosophila melanogasterDrosophila ProteinsLithiumLithium ChlorideAnimalsMalpighian TubulesMutationNeurogliaAmino Acid Transport SystemsDrosophila ProteinsLithiumLithium ChlorideAmino acid metabolismDrosophila melanogasterLithiumMalpighian tubulesMetabolomic analysisOxidative stress

Identifiers

PMID40194719
PMCPMC12129673

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.