ArticleG3 (Bethesda, Md.)2025
The genome of the MZM-0403 strain of the African turquoise killifish, Nothobranchius furzeri.
Article in G3 (Bethesda, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A short-lived fish with long-lasting effects: hallmarks of aging inFrontiers in aging · 2025Review
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Authors and funding
3 authors.
Funding
Abstract
The African turquoise killifish, Nothobranchius furzeri, is an emerging model for functional genomics research. Interest in N. furzeri stems from its extremely short lifespan, and the breadth of research on this fish is rapidly expanding. All currently available whole-genome assemblies for N. furzeri are based on the GRZ strain. However, N. furzeri shows substantial phenotypic differences among populations. Here, we present a whole-genome assembly of the MZM-0403 strain of N. furzeri, which differs from the GRZ strain with respect to lifespan and male coloration patterns. We used PacBio HiFi sequencing to sequence the genome of an MZM-0403 male to ∼48 × coverage. The PacBio reads were de novo assembled and then scaffolded against an existing N. furzeri genome assembly. This strategy resulted in a chromosome-level assembly. Our MZM-0403 assembly differs from previous N. furzeri assemblies in that it is closer to the expected genome size based on independent estimates (∼1.5 Gb) and it has substantially fewer gaps, particularly in the vicinity of genes and within introns. A repeat analysis shows that about two-thirds of the genome is composed of repetitive elements. In addition, our assembly approach allowed us to recover phased fragments of the X- and Y-chromosomes. Analysis of these regions identifies 20 genes that are likely in the nonrecombining region of the sex chromosomes. Overall, this novel genome assembly will be useful for future functional and comparative genomics studies of fishes in the genus Nothobranchius.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.