Evidence map›Paper›PMID 40194457›Full record

ArticleJournal of neurosurgery. Case lessons2025

To patch or not to patch: is that the real question? The role of hemodynamics in carotid endarterectomy. Illustrative cases.

Tatiana Abou-Mrad, Laura Stone McGuire, Laurel Morgan Miller Marsh, Juan Cebral, Fady T Charbel

Abstract read
In one paragraph

Article in Journal of neurosurgery. Case lessons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tatiana Abou-MradDepartment of Neurosurgery, University of Illinois Chicago, Illinois.ORCID 0009-0007-0340-5846
Laura Stone McGuireDepartment of Neurosurgery, University of Illinois Chicago, Illinois.ORCID 0000-0001-8063-9389
Laurel Morgan Miller MarshDepartment of Bioengineering, George Mason University, Fairfax, Virginia.
Juan CebralDepartment of Bioengineering, George Mason University, Fairfax, Virginia.
Fady T CharbelDepartment of Neurosurgery, University of Illinois Chicago, Illinois.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe utilizationof patches in carotid endarterectomy (CEA) for carotid artery stenosis remains controversial, with conflicting evidence regarding postoperative outcomes. This report accentuates this discourse with two selected representative cases with divergent outcomes. OBSERVATIONS: Computational fluid dynamics analyses of pre- and post-CEA hemodynamics revealed distinct hemodynamic profiles between the two patients. In the nonpatched internal carotid artery (ICA), the vessel retained a cylindrical shape, exhibiting swirling blood flow and higher wall shear stress (WSS)-patterns typical of healthy vasculature. The patched ICA adopted a bulbous shape, akin to the anatomical carotid bulb, and displayed lower WSS and noncoherent disturbed blood flow, which are features associated with atherosclerosis, endothelial dysfunction, and cellular damage. LESSONS: This study suggests that the question may not be "To patch or not to patch?" but rather "Is the restoration of the anatomical bulb shape beneficial or deleterious?" It sheds light on the hemodynamic implications of this procedure and provides insight into the ongoing debate surrounding CEA. Using a patch might not necessarily result in improved flow or more favorable outcomes; thus, restoration of the carotid bulb configuration postendarterectomy might not optimize the hemodynamic profile for patients, but rather, a simple tubular shape, without a patch, might offer the best solution. https://thejns.org/doi/10.3171/CASE24840.

Indexed as

carotid endarterectomycarotid stenosiscomputational fluid dynamicshemodynamicspatchstroke

Identifiers

PMID40194457
PMCPMC11976021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.