ArticleThe journal of physical chemistry letters2025
X-ray Absorption Spectroscopy of Dilute Metalloenzymes at X-ray Free-Electron Lasers in a Shot-by-Shot Mode.
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Article in The journal of physical chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
35 authors.
Isabel BogaczMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0003-1493-3867
Erzsi SzilagyiMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0009-0006-8585-6167
Hiroki MakitaMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Philipp S SimonMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-2859-4475
Miao ZhangMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Margaret D DoyleMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-7289-3544
Kuntal ChatterjeeMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Moritz KretzschmarMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Petko ChernevMolecular Biomimetics, Department of Chemistry - Ångström, Molecular Biomimetics, Uppsala University, SE 75120 Uppsala, Sweden.
Nicholas CroyMolecular Biomimetics, Department of Chemistry - Ångström, Molecular Biomimetics, Uppsala University, SE 75120 Uppsala, Sweden.
Mun-Hon CheahMolecular Biomimetics, Department of Chemistry - Ångström, Molecular Biomimetics, Uppsala University, SE 75120 Uppsala, Sweden.ORCID 0000-0001-5732-1524
Medhanjali DasguptaMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Isabela NangcaMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0003-4159-1970
Thomas FranssonDepartment of Theoretical Chemistry and Biology, KTH Royal Institute of Technology, 114 28 Stockholm, Sweden.ORCID 0000-0002-3770-9780
Asmit BhowmickMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-6154-6635
Aaron S BrewsterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-0908-7822
Nicholas K SauterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0003-2786-6552
Shigeki OwadaJapan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan.
Kensuke TonoJapan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan.
Serhane ZerdaneSwissFEL, Paul Scherrer Institut, 5232 Villigen, Switzerland.
Alexander OggenfussSwissFEL, Paul Scherrer Institut, 5232 Villigen, Switzerland.
Danylo BabichSwissFEL, Paul Scherrer Institut, 5232 Villigen, Switzerland.
Mathias SanderSwissFEL, Paul Scherrer Institut, 5232 Villigen, Switzerland.
Roman MankowskySwissFEL, Paul Scherrer Institut, 5232 Villigen, Switzerland.
Henrik T LemkeSwissFEL, Paul Scherrer Institut, 5232 Villigen, Switzerland.
Leland B GeeLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0002-5817-3997
Takahiro SatoLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.
Thomas KrollSSRL, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0003-2176-6905
Johannes MessingerMolecular Biomimetics, Department of Chemistry - Ångström, Molecular Biomimetics, Uppsala University, SE 75120 Uppsala, Sweden.ORCID 0000-0003-2790-7721
Roberto Alonso-MoriLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0002-5357-0934
Uwe BergmannDepartment of Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0001-5639-166X
Dimosthenis SokarasSSRL, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0001-8117-1933
Vittal K YachandraMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-3983-7858
Jan KernMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-7272-1603
Junko YanoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0001-6308-9071
Funding
A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3MStructural Dynamics at LCLSP41GM139687 · NIGMS · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2021 to 2025
$7.5MBiological Spectroscopy and Crystallography Using an X-ray Free Electron Laser - Supplemental EquipmentR01GM110501 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Junko Yano · 2014 to 2026
$4.8MHigh throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniquesR01GM126289 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KERN, JAN F · 2017 to 2025
$4.6MDIALS: supporting structural biology through open source diffraction processing softwareR24GM154040 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Aaron Samuel Brewster · 2024 to 2026
$3.7MTaking Snapshots of Enzymatic Reactions Using X-ray Crystallography and SpectroscopyR35GM149528 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VITTAL YACHANDRA · 2023 to 2026
$2.7MCctbx.xfel: Serial crystallography computational methods aimed at biomolecular functionR35GM151988 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI NICHOLAS K SAUTER · 2024 to 2026
$2.2MNIGMS NIH HHS P30 GM133894NIGMS NIH HHS P41 GM139687NIGMS NIH HHS R01 GM110501NIGMS NIH HHS R01 GM126289NIGMS NIH HHS R24 GM154040NIGMS NIH HHS R35 GM149528NIGMS NIH HHS R35 GM151988
Abstract
X-ray absorption spectroscopy (XAS) of 3d transition metals provides important electronic structure information for many fields. However, X-ray-induced radiation damage under physiological temperature has prevented using this method to study dilute aqueous systems, such as metalloenzymes, as the catalytic reaction proceeds. Here we present a new approach to enable
Indexed as
LasersManganeseMetalloproteinsPhotosystem II Protein ComplexPhotosystem I Protein ComplexX-Ray Absorption SpectroscopyElectronsIronIronManganeseMetalloproteinsPhotosystem II Protein ComplexPhotosystem I Protein Complex
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.