Evidence map›Paper›PMID 40193703›Full record

ArticleJournal of medicinal chemistry2025

Novel Spiro-Barbiturates Can Reverse the Action of General Anesthetics on the GABA

Dimosthenis Koinas, Xiaojuan Zhou, Bo Wu, Keith W Miller, Karol S Bruzik

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dimosthenis KoinasDepartment of Pharmaceutical Sciences, University of Illinois Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, United States.ORCID 0000-0002-6684-931X
Xiaojuan ZhouDepartment of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, United States.
Bo WuDepartment of Pharmaceutical Sciences, University of Illinois Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, United States.
Keith W MillerDepartment of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, United States.
Karol S BruzikDepartment of Pharmaceutical Sciences, University of Illinois Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, United States.ORCID 0000-0003-0678-4232

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Molecular Pharmacology of the Synaptic and Extrasynaptic GABA(A) ReceptorsR01GM135550 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 2020 to 2023
$2.8M
NIGMS NIH HHS P41 GM103311NIGMS NIH HHS R01 GM135550
6 · The paper itself

Abstract

GABA

Indexed as

Anesthetics, GeneralBarbituratesReceptors, GABA-ASpiro CompoundsAllosteric RegulationAnimalsHumansStructure-Activity RelationshipAnesthetics, GeneralBarbituratesReceptors, GABA-ASpiro Compounds

Identifiers

PMID40193703
PMCPMC12191442

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.