ReviewMedicine2025
A case report and literature review of self-improving collodion baby in the newborn.
Review in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Novel Compound Heterozygous Variants inJournal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSelf-improving collodion baby (SICB) is a rare subtype of autosomal recessive congenital ichthyosis with distinct clinical features and generally favorable prognosis. This study aims to enhance understanding of SICB by examining its clinical characteristics and recent developments in diagnosis and management. Our findings provide insights that may aid in the etiological diagnosis and treatment of congenital ichthyosis. PATIENT CONCERNS: We present a case of SICB treated at Peking University Shenzhen Hospital, characterized by the appearance of a collodion membrane at birth. The primary approach involved intensive moisturizing care to manage skin abnormalities. DIAGNOSES: Based on clinical examination and genetic testing, a diagnosis of SICB was confirmed, with mutations identified in genes commonly associated with autosomal recessive congenital ichthyosis, such as ALOX12B, TGM1, ALOXE3, CYP4F22, and PNPLA1. OUTCOMES: The patient showed significant improvement following targeted supportive care, consistent with the generally positive prognosis for SICB. LESSONS: A comprehensive literature review of 31 SICB cases from 18 studies highlighted that the condition typically presents at birth with a collodion membrane. Intensive moisturizing is the main treatment, and early genetic testing is recommended to facilitate timely diagnosis and intervention. Early diagnosis can support effective genetic counseling and improve outcomes for newborns with ichthyosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.