ArticleProceedings of the National Academy of Sciences of the United States of America2025
Whole-brain white matter variation across childhood environments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Early psychosocial deprivation alters the refinement of neural dynamics across adolescence.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Early‑life head circumference is causally associated with adult executive function through cortical surface area expansion.Developmental cognitive neuroscience · 2026Article
- Demographics change the relationships between socioeconomic status, white matter network organization, and cognition in children.Developmental cognitive neuroscience · 2026Article
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- Friends, family, and community influences on adolescent development: A review of impactful findings from the ABCD study®.Developmental cognitive neuroscience · 2026Article
- Nutrition, Cognition and Learning: The Role of White Matter Development and Connectivity.medRxiv : the preprint server for health sciences · 2026Article
- Neighborhood opportunity, white matter, and cognition in a large pediatric neuroimaging study.Translational psychiatry · 2026Article
- Advancing child health: forecasting the next great research achievements.Pediatric research · 2026Article
- White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026Article
- Whole-Brain Fractional Anisotropy, Centered on the Superior Longitudinal Fasciculus, Is Positively Correlated With Urban Aesthetic Perception.Brain and behavior · 2026Article
- Brain controllability mediates the effects of early life adversity on adolescent behavior and cognition moderated by genetic risks.Research square · 2026Article
- Deviation in development of dorsal association tracts during preadolescence links to concurrent and future cognitive performance and transdiagnostic psychopathology.Nature communications · 2026Article
- Validation of socialbit as a smartwatch algorithm for social interaction detection in a clinical population.Scientific reports · 2026Article
- Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
White matter develops over the course of childhood in an experience-dependent manner. However, its role in the relationship between the early environment and later cognition is unclear, in part due to focus on changes in specific gray matter regions. This study examines white matter differences across adolescents from diverse environments, evaluating both their extent throughout the brain and their contribution to cognitive outcomes. Using data from the Adolescent Brain Cognitive Development (ABCD) study (N = 9,082, female = 4,327), we found extensive cross-sectional associations with lower white matter fractional anisotropy (FA) and streamline count in the brains of 9- and 10-y-old children exposed to a range of experiences, including prenatal risk factors, interpersonal adversity, household economic deprivation, and neighborhood adversity. Lower values of FA were associated with later difficulties with mental arithmetic and receptive language. Furthermore, white matter FA partially mediated the detrimental relationship between adversity and cognition later in adolescence. These findings advance a white matter-based account of the neural and cognitive effects of adversity, which supports leading developmental theories that place interregional connectivity prior to gray matter maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.