Evidence map›Paper›PMID 40193440›Full record

Observational studyJournal of psychopathology and clinical science2025

Expanding the scope of the withdrawal syndrome: Anhedonia as a core nicotine withdrawal symptom.

Jennifer M Betts, Timothy B Baker, Daniel M Bolt, Deejay Zwaga, Megan E Piper, Danielle E McCarthy, Tanya R Schlam, Jesse T Kaye, Adrienne L Johnson, Jessica W Cook

Abstract readObservational Study
In one paragraph

Observational study in Journal of psychopathology and clinical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Exploring the nature and relationship of tobacco cigarette craving and withdrawal.Journal of psychopathology and clinical science · 2026
    Article
  2. Assessing cigarette smoking withdrawal in unmedicated individuals: Validating the Wisconsin Smoking Withdrawal Scales Version 3 (WSWS3).Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
    Article
  3. Article
  4. Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer M BettsCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.ORCID 0000-0003-3943-5848
Timothy B BakerCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.
Daniel M BoltCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.
Deejay ZwagaCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.
Megan E PiperCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.
Danielle E McCarthyCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.
Tanya R SchlamCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.
Jesse T KayeCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.
Adrienne L JohnsonCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.
Jessica W CookCenter for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison.

Funding

Enhancing the Effectiveness of Varenicline Based Smoking Cessation TreatmentR01HL109031 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TIMOTHY B, STEIN, JAMES H · 2011 to 2020
$17.5M
NHLBI NIH HHS R01 HL109031US Department of Veterans AffairsWellcome Trust
6 · The paper itself

Abstract

Some evidence suggests that anhedonia is a component of nicotine withdrawal, but additional research is needed to support this conclusion and establish its clinical relevance. Secondary analyses were conducted for a comparative effectiveness smoking cessation clinical trial of combination nicotine replacement therapy, nicotine patches, and varenicline (

Indexed as

AnhedoniaNicotineSmoking CessationSubstance Withdrawal SyndromeTobacco Use Cessation DevicesTobacco Use DisorderAdultFemaleHumansMaleMiddle AgedNicotinic AgonistsSecondary Data AnalysisSmoking Cessation AgentsVareniclineNicotineNicotinic AgonistsSmoking Cessation AgentsVarenicline

Identifiers

PMID40193440
PMCPMC12162215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.