ArticlePLoS biology2025
The zona incerta negatively regulates the red nucleus during movement cued by sound signals.
Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Red Nucleus Excitatory Neurons Initiate Directional Motor Movement in Mice.Biomedicines · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auditory signal-cued behaviors rely on a sophisticated neural network. While extensive research has focused on auditory processing and decision-making, the neural circuits governing motor coordination for goal-directed actions remain poorly understood. The red nucleus (RN) is essential for motor coordination, whereas the zona incerta (ZI) plays a key role in modulating sensorimotor circuits. Using tetrode recordings and optogenetics, we investigated the ZI-RN circuit's role in an auditory-cued decision task. RN neurons were preferentially activated when mice moved to the contralateral port for a reward, and optogenetic activation biased choices toward the contralateral side. Notably, parvalbumin-positive ZI neurons projected to the RN and negatively regulated movement coordination. These findings reveal an inhibitory ZI-RN circuit that shapes auditory-cued, goal-directed movement.
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