Evidence map›Paper›PMID 40193205›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Synthesis of 2-(Trifluoromethyl)Azetidines by Strain-Release Reactions of 2-(Trifluoromethyl)-1-Azabicyclo[1.1.0]Butanes.

Anaïs Scuiller, Alexandre Dupas, Gauthier Lefebvre, Naïssa Bouriche, Henri Chédotal, Gérard Guillamot, Janine Cossy, Christophe Meyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anaïs ScuillerMolecular, Macromolecular Chemistry, and Materials, ESPCI Paris - PSL, CNRS, 10 rue Vauquelin, Paris, France.
Alexandre DupasMolecular, Macromolecular Chemistry, and Materials, ESPCI Paris - PSL, CNRS, 10 rue Vauquelin, Paris, France.
Gauthier LefebvreMolecular, Macromolecular Chemistry, and Materials, ESPCI Paris - PSL, CNRS, 10 rue Vauquelin, Paris, France.
Naïssa BouricheMolecular, Macromolecular Chemistry, and Materials, ESPCI Paris - PSL, CNRS, 10 rue Vauquelin, Paris, France.
Henri ChédotalMolecular, Macromolecular Chemistry, and Materials, ESPCI Paris - PSL, CNRS, 10 rue Vauquelin, Paris, France.
Gérard GuillamotSeqens, ZI de Limay, 2-8 rue de Rouen, Porcheville, France.
Janine CossyMolecular, Macromolecular Chemistry, and Materials, ESPCI Paris - PSL, CNRS, 10 rue Vauquelin, Paris, France.ORCID https://orcid.org/0000-0001-8746-9239
Christophe MeyerMolecular, Macromolecular Chemistry, and Materials, ESPCI Paris - PSL, CNRS, 10 rue Vauquelin, Paris, France.ORCID https://orcid.org/0000-0003-3420-5584

Funding

Institut Carnot IPGG MicrofluidicsSeqens
6 · The paper itself

Abstract

Substituted azetidines are privileged heterocyclic scaffolds in medicinal chemistry and have become synthetic targets of high interest in recent years. With the goal of developing a new access to azetidines incorporating the pharmaceutically relevant trifluoromethyl group, the reactivity of 2-(trifluoromethyl)-1-azabicyclo[1.1.0]butanes was investigated in polar strain-release reactions. By using benzyl chloroformate or trifluoroacetic anhydride as reacting partners, diversely substituted 3-chloroazetidines, 3-substituted azetidines and azetidin-3-ols bearing a trifluoromethyl group at C2 could be readily synthesized. In addition, palladium-catalyzed hydrogenolysis reactions provided an entry to cis-3-aryl-2-trifluoromethyl azetidines.

Indexed as

azabicyclo[1.1.0]butaneazetidinefluorinestrained moleculesstrain‐release reactions

Identifiers

PMID40193205
PMCPMC12099193

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.